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1- (1- (2,3,3alpha,4,5,6- hexahydro- 1H- phenalen- 1- yl)piperidin- 4- yl)indolin- 2- one

a ligand of both ociceptin/orphanin FQ peptide receptor and mu-opioid receptor

Also Known As:

SR16435

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1-(1-(2,3,3alpha,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl)indolin-2-one: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenalenes: 1
        1-(1-(2,3,3alpha,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl)indolin-2-one: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenalenes: 1
    - 1-(1-(2,3,3alpha,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl)indolin-2-one: 1

Experts

1.	Husbands, Stephen M: 1 article (07/2013)
2.	Ko, Mei-Chuan: 1 article (07/2013)
3.	Sukhtankar, Devki D: 1 article (07/2013)
4.	Zaveri, Nurulain T: 1 article (07/2013)

Related Diseases

1.	Pain (Aches) 07/01/2013 - "Antinociceptive effects of bifunctional NOP/MOP ligands BU08028 [(2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol] and SR16435 [1-(1-(2,3,3α,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl)-indolin-2-one] were pharmacologically compared with the putative bifunctional ligand buprenorphine, selective NOP agonist SCH221510 [3-endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol] and selective MOP agonist morphine in neuropathic and inflammatory pain models. "
2.	Inflammation (Inflammations) 07/01/2013 - "Our data indicated that BU08028 and SR16435 were more potent than morphine and SCH221510 in attenuating nerve injury-induced tactile allodynia and inflammation-induced thermal hyperalgesia. "
3.	Hyperalgesia 07/01/2013 - "Our data indicated that BU08028 and SR16435 were more potent than morphine and SCH221510 in attenuating nerve injury-induced tactile allodynia and inflammation-induced thermal hyperalgesia. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Ligands
3.	Buprenorphine (Subutex)
4.	2- (N- cyclopropylmethyl- 4,5- epoxy- 6,14- ethano- 3- hydroxy- 6- methoxymorphinan- 7- yl)- 3,3- dimethylpentan- 2- ol
5.	8- (bis(2- methylphenyl)methyl)- 3- phenyl- 8- azabicyclo(3.2.1)octan- 3- ol