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2- ((4- (1- (2- fluoroethyl)- 4- (4- pyridinyl)- 1H- pyrazol- 3- yl)phenoxy)methyl)- 3,5- dimethylpyridine

a radioligand for imaging phosphodiesterase 10A; structure in first source

Also Known As:

18F-JNJ42259152; 2-((4-(1-(2-(18F)fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine; JNJ42259152

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 2-((4-(1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine: 1
  - Pyridines: 88
    - 2-((4-(1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine: 1

Experts

1.	Niccolini, Flavia: 1 article (06/2016)
2.	Pagano, Gennaro: 1 article (06/2016)
3.	Politis, Marios: 1 article (06/2016)

Related Diseases

1.

Disease Progression

06/01/2016 - "Brain metabolism ([(18)F]FDG and [(15)O]H2O), presynaptic ([(18)F]fluorodopa, [(11)C]β-CIT and [(11)C]DTBZ) and postsynaptic ([(11)C]SCH22390, [(11)C]FLB457 and [(11)C]raclopride) dopaminergic function, phosphodiesterases ([(18)F]JNJ42259152, [(18)F]MNI-659 and [(11)C]IMA107), and adenosine ([(18)F]CPFPX), cannabinoid ([(18)F]MK-9470), opioid ([(11)C]diprenorphine) and GABA ([(11)C]flumazenil) receptors were evaluated as potential biomarkers for monitoring disease progression and for assessing the development and efficacy of novel disease-modifying drugs in premanifest HD carriers and HD patients. "

Related Drugs and Biologics

1.	Raclopride
2.	Biomarkers (Surrogate Marker)
3.	Phosphoric Diester Hydrolases (Phosphodiesterases)
4.	gamma-Aminobutyric Acid (GABA)
5.	Flumazenil (Romazicon)
6.	Diprenorphine
7.	Cannabinoids
8.	Opioid Analgesics (Opioids)
9.	Adenosine (Adenocard)
10.	fluorodopa F 18