FK886

structure in first source

Also Known As:

((3,5-bis(trifluoromethyl)phenyl)((2R)-2-(3-hydroxy-4-methylbenzyl)-4-(2-((2S)-2-methoxymethyl)morpholin-4-yl)ethyl)piperazin-1-yl)methanone dihydrochloride

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - FK886: 2
  - Oxazines: 9
    - Morpholines: 6
      - FK886: 2

Experts

1.	Furukawa, Takako Yoshino: 2 articles (01/2014 - 01/2013)
2.	Imazumi, Katsunori: 2 articles (01/2014 - 01/2013)
3.	Manda, Toshitaka: 2 articles (01/2014 - 01/2013)
4.	Matsuo, Masahiko: 2 articles (01/2014 - 01/2013)
5.	Nakayama, Hiroe: 2 articles (01/2014 - 01/2013)
6.	Takeshita, Koji: 2 articles (01/2014 - 01/2013)
7.	Uchida, Wataru: 2 articles (01/2014 - 01/2013)
8.	Yamakuni, Hisashi: 2 articles (01/2014 - 01/2013)
9.	Kikuchi, Aya: 1 article (01/2013)
10.	Sogabe, Hajime: 1 article (01/2013)

Related Diseases

Vomiting

01/01/2013 - "Nearly complete inhibition was observed at 1 mg/kg. At an equivalent dose range, orally administered FK886 also significantly inhibited emesis, indicating good oral absorption. "
01/01/2014 - "These results suggest that FK886 is an orally available NK1 receptor antagonist which is effective against both the acute and delayed emesis induced by cisplatin. "
01/01/2014 - "In the same study, oral FK886 (3.2 mg/kg) repeatedly administrated at 12-h intervals, the first dose being administered 36 h post cisplatin, also significantly attenuated the delayed emesis. "
01/01/2014 - "In addition, rapid brain penetration of FK886 was suggested by complete and near complete inhibition of GR73632- and copper sulfate-induced emesis, respectively, by low-dose intravenous FK886 administered shortly before the emetogens. "
01/01/2013 - "The effects were long lasting, with 1.6 mg/kg of FK886 completely blocking apomorphine-induced retching and vomiting after a 12-h pretreatment period. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Antiemetics
3.	Emetics
4.	Neurokinin-1 Receptor Antagonists
5.	Copper Sulfate (Sulfate, Copper)
6.	Apomorphine

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Intravenous Administration