N- (2- (5- methoxy- indol- 3- yl)- ethyl)- 4- oxo- 4H- pyran- 2- carboxamide

03/15/2014 - "The objective of this study was to investigate the effects of piromelatine on insulin sensitivity in sleep restricted rats. "
03/15/2014 - "We conclude that piromelatine could regulate metabolic profiles and insulin sensitivity, and attenuate insulin resistance induced by sleep restriction. "
06/01/2010 - "Support of insulin sensitivity may become a new area of application for compounds such as NEU-P11. "
04/01/2009 - "We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity."
03/15/2014 - "Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats."

01/01/2018 - "The results showed that piromelatine prevented the suppression of body weight gain and energy intake induced by CF and normalized CF-induced hyperglycemia and homeostasis model assessment-IR index, which suggests that piromelatine prevented whole-body IR. "
04/01/2009 - "We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity."
04/01/2009 - "Our results showed that NEU-P11 or melatonin inhibited both body weight gain and deposit of abdominal fat with no influence on food intake. "
04/01/2009 - "These data suggest that NEU-P11, like melatonin, decreased body weight gain and improved insulin sensitivity and metabolic profiles in obese rats. "
09/01/2013 - "Piromelatine, similar to melatonin, has an antihypertensive effect and also attenuates body weight, improves metabolic profiles and might be useful in the treatment of hypertension and the metabolic syndrome."

01/01/2018 - "In conclusion, piromelatine might be a novel therapeutic agent for glucose intolerance and IR."
10/05/2017 - "The results showed that the increased food intake, water consumption, hyperglycemia, glucose intolerance, and insulin resistance in T2DM rats were all improved by Neu-P11 treatment. "

08/01/2013 - "Piromelatine, a novel investigational multimodal sleep medicine, is developed for the treatment of patients with primary and co-morbid insomnia. "
10/01/2022 - "We applied this model to evaluate the efficacy of piromelatine (Pir), a novel melatonin analog developed for the treatment of insomnia, in male and female offspring. "
04/01/2009 - "NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. "
09/08/2022 - "The melatonin (MT) analogue Piromelatine (Pir) was designed for the treatment of insomnia. "
03/15/2014 - "Piromelatine (Neu-P11) is a novel melatonin agonist, which has been developed for the treatment of insomnia. "

01/01/2016 - "The aim of this study was to determine whether piromelatine ameliorates chronic mild stress (CMS)-induced memory deficits and explore the underlying mechanisms. "
01/09/2023 - "Sex-Dependent Effect of Chronic Piromelatine Treatment on Prenatal Stress-Induced Memory Deficits in Rats."
01/01/2016 - "Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats."
01/01/2016 - "Piromelatine ameliorates memory deficits associated with CMS-induced anhedonia in rats and this effect may be mediated by restoring hippocampal BDNF, CREB, and cytogenesis deficits."