HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
1- (3- (1- methyl- 1H- pyrazol- 4- yl)- 5- oxo- 5H- benzo(4,5)cyclohepta(1,2- b)pyridin- 7- yl)- N- (pyridin- 2- ylmethyl)methanesulfonamide
inhibits both Ron and c-Met kinases; structure in first source
Also Known As:
MK-8033
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Sulfonamides: 2809
1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide: 1
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Benzocycloheptenes
1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide: 1
Sulfur Compounds: 278
Sulfones: 534
Sulfonamides: 2809
1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Benzocycloheptenes
1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide: 1
Experts
1.
Berlin, Jordan D
: 1 article (10/2018)
2.
Camacho, Luis H
: 1 article (10/2018)
3.
Keedy, Vicki L
: 1 article (10/2018)
4.
Lenz, Heinz-Josef
: 1 article (10/2018)
5.
Saltz, Leonard
: 1 article (10/2018)
6.
Whisenant, Jennifer G
: 1 article (10/2018)
Related Diseases
1.
Neoplasms (Cancer)
10/01/2018 - "
First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors.
"
10/01/2018 - "
MK-8033 is a small-molecule inhibitor of c-Met that binds preferentially to the activated conformation, and has demonstrated anti-tumor activity in preclinical models.
"