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N3-methyladenine

structure in first source

Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        N3-methyladenine: 13

Experts

1.	Gold, Barry: 6 articles (01/2013 - 06/2004)
2.	Varadarajan, Sridhar: 2 articles (01/2017 - 06/2004)
3.	Bobola, Michael S: 2 articles (01/2013 - 06/2004)
4.	Iyer, Prema: 2 articles (01/2013 - 07/2010)
5.	Silber, John R: 2 articles (01/2013 - 06/2004)
6.	Graziani, Grazia: 2 articles (02/2005 - 07/2002)
7.	Tentori, Lucio: 2 articles (02/2005 - 07/2002)
8.	Bartolotti, Libero J: 1 article (01/2017)
9.	Bourdelais, Andrea J: 1 article (01/2017)
10.	Buchanan, Mairin K: 1 article (01/2017)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 01/17/2017 - "This molecule produces exclusively N3-methyladenine adducts upon reaction with DNA and is an order of magnitude more toxic to treatment resistant human glioblastoma cells than streptozotocin is, a Food and Drug Administration-approved, glycoconjugated DNA-methylating drug. " 05/01/2023 - "Studies have demonstrated that alkyladenine DNA glycosylase (AAG), an enzyme that triggers the base excision repair (BER) pathway by excising TMZ-induced N3-methyladenine (3meA) and N7-methylguanine lesions, is overexpressed in glioblastoma tissues compared to normal tissues. "
2.	Leukemia 02/01/2005 - "In the present study, we show that MeOSO(2) (CH(2))(2)-lexitropsin (Me-Lex), a compound generating almost exclusively N3-methyladenine (>99%), provoked a burst of poly(ADP-ribosylation) and loss of mitochondrial membrane potential in leukemia cells. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/01/2007 - "In the present work, we have extended previous studies in which mice deficient in the repair of N3-methyladenine adducts, 3-methyladenine DNA glycosylase (alkyladenine DNA glycosylase [Aag]) null mice, were reported to be resistant to the direct cytotoxic effect of STZ, but later developed autoimmune diabetes (J. "
4.	Neoplasms (Cancer) 02/01/2007 - "Furthermore, tumor development is not observed in Aag(-/-) treated mice, suggesting that N3-methyladenine adducts that accumulate in the genome may not be promutagenic in beta-cells." 07/01/2002 - "The potential use of N3-methyladenine selective agents in the case of tumors tolerant to O6-methylguanine will be also discussed." 04/01/1993 - "Therefore, these increased repair activities may play an important role in removing the lethal N3-methyladenine residues, the promutagenic O6-methylguanine lesions, and the potentially lethal chloroethyl adducts formed by the nitrosoureas used in cancer chemotherapy more efficiently from the cellular DNA." 11/18/2010 - "DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excising cytotoxic N3-methyladenine bases formed by DNA-targeting anticancer compounds. "
5.	Genomic Instability 07/01/2010 - "XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine."

Related Drugs and Biologics

1.	3-methyladenine-DNA glycosylase
2.	methyl lexitropsin
3.	7-methylguanine
4.	Enzymes
5.	DNA (Deoxyribonucleic Acid)
6.	O-(6)-methylguanine
7.	Ribosome Inactivating Proteins
8.	DNA Glycosylases (DNA Glycosylase)
9.	DNA Repair Enzymes
10.	DNA Adducts

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)