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astragaloside II

a potent multidrug resistance (MDR) reversal agent from Astragalus; structure in first source

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - astragaloside II: 15

Experts

1.	Huang, Can: 2 articles (06/2017 - 12/2012)
2.	Su, Yong: 2 articles (06/2017 - 12/2012)
3.	Xia, Quan: 2 articles (06/2017 - 12/2012)
4.	Arunagirinathan, Narasingam: 1 article (03/2021)
5.	DU, Fengxia: 1 article (03/2021)
6.	Divyadarshini, Angamuthu: 1 article (03/2021)
7.	Indu, Purushothaman: 1 article (03/2021)
8.	Jiang, Yang: 1 article (03/2021)
9.	Jin, Haifeng: 1 article (03/2021)
10.	Li, Xuemei: 1 article (03/2021)

Related Diseases

1.	Liver Neoplasms (Liver Cancer) 12/01/2012 - "The results suggested that Astragaloside II is a potent MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy." 06/01/2017 - "Our previous reports showed that Astragaloside II improves hepatic cancer cells resistance by downregulating MDR1 and P-gp .The purpose of this study was to further investigated the effect of autophagy on AS-II reversing multidrug resistance and its molecular mechanism in hepatocellular carcinoma cells in vitro. " 12/01/2012 - "Astragaloside II (0.08 mg/ml) showed strong potency to increase 5-fluorouracil cytotoxicity toward 5-fluorouracil-resistant human hepatic cancer cells Bel-7402/FU. " 12/01/2012 - "Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II."
2.	Weight Loss (Weight Reduction) 05/01/2011 - "Astragaloside II was the most toxic Astragalus component with 5-10 % weight loss at a dose of 500 µg while astragaloside IV showed no weight loss at all at this dose, suggesting that astragaloside IV might be utilized as an immunological adjuvant in future studies. "
3.	Hepatocellular Carcinoma (Hepatoma) 06/01/2017 - "Our previous reports showed that Astragaloside II improves hepatic cancer cells resistance by downregulating MDR1 and P-gp .The purpose of this study was to further investigated the effect of autophagy on AS-II reversing multidrug resistance and its molecular mechanism in hepatocellular carcinoma cells in vitro. " 06/01/2017 - "Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy."
4.	Dengue (Dengue Fever) 03/01/2021 - "In silico ADMET analysis revealed that astragaloside II, III, and IV were non-mutagenic and non-carcinogenic in nature and these compounds were also non-toxic to vero cells upto 1000 μg/mL. Against dengue virus serotype 3, astragaloside II exhibited substantial antiviral activity at the concentration of 1.56 μg/mL followed by astragaloside III at 6.25 μg/mL and astragaloside IV at 12.5 μg/mL. Also, against dengue serotype 1, astragaloside II showed the maximum antiviral activity at 1.56 μg/mL followed by astragaloside III and IV at 3.125 μg/mL. This study concludes that astragaloside II, III, and IV compounds had potential in vitro anti-dengue virus activity."
5.	Ovarian Neoplasms (Ovarian Cancer) 09/01/2023 - "Astragaloside II enhanced sensitivity of ovarian cancer cells to cisplatin via triggering apoptosis and autophagy." 06/13/2017 - "The results suggested that the pharmacodynamic basis of LCSSY on anti-ovarian cancer activities were germacrone, furandiene, β-elemene, calycosin-7-glucoside, ononin, epimedin B, icariin, ginsenoside Rc, astragaloside, ginsenoside Rd, astragaloside II, and some unknown components."

Related Drugs and Biologics

1.	astragaloside A
2.	Antiviral Agents (Antivirals)
3.	Immunologic Adjuvants (Immunologic Adjuvant)
4.	astragaloside III
5.	calycosin-7-O-beta-D-glucoside
6.	Fluorouracil (Carac)
7.	7,3'-dihydroxy-4'-methoxyisoflavone
8.	Member 1 Subfamily B ATP Binding Cassette Transporter
9.	Cytochrome P-450 CYP1A2 (CYP1A2)
10.	Cytochrome P-450 CYP1A1 (CYP1A1)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)