Nonsyndromic Holoprosencephaly

Also Known As:

Isolated Holoprosencephaly; Isolated Hpe; Non-Syndromic, Non-Chromosomal Holoprosencephaly; Non-Syndromic, Non-Chromosomal Hpe; Nonsyndromic Hpe

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Musculoskeletal Abnormalities: 43
  - Craniofacial Abnormalities: 203
    - Holoprosencephaly: 219
      - Nonsyndromic Holoprosencephaly: 4
Nervous System Diseases: 14178
- Nervous System Malformations: 35
  - Agenesis of Corpus Callosum: 54
    - Holoprosencephaly: 219
      - Nonsyndromic Holoprosencephaly: 4
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
- Inborn Genetic Diseases: 11939
  - Chromosome Disorders: 136
    - Holoprosencephaly: 219
      - Nonsyndromic Holoprosencephaly: 4

Experts

1.	Babovic-Vuksanovic, Dusica: 1 article (09/2014)
2.	Dhamija, Radhika: 1 article (09/2014)
3.	Ferber, Matthew J: 1 article (09/2014)
4.	Kirmani, Salman: 1 article (09/2014)
5.	Lazaridis, Konstantinos N: 1 article (09/2014)
6.	Wang, Xiangling: 1 article (09/2014)
7.	Wieben, Eric D: 1 article (09/2014)
8.	Chodirker, Bernard: 1 article (04/2012)
9.	Chudley, Albert E: 1 article (04/2012)
10.	Prasad, Asuri N: 1 article (04/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nonsyndromic Holoprosencephaly:

1.	OligonucleotidesIBA 09/01/2014 - "Previous studies included a normal karyotype, oligonucleotide array, and single gene testing for nonsyndromic holoprosencephaly (SHH, SIX3, ZIC2, TGIF). "
2.	VitaminsIBA 04/01/2012 - "The use of periconceptional folic acid or vitamins was not associated with a lower risk of nonsyndromic HPE."
3.	Transcription Factors (Transcription Factor)IBA 04/01/2001 - "We report on the prevalence of mutations in the zinc finger transcription factor gene, ZIC2, in a group of 509 unrelated individuals with isolated holoprosencephaly (HPE) and normal chromosomes. "
4.	SalicylatesIBA 02/14/2000 - "Maternal periconceptional exposures associated with increased risks for nonsyndromic holoprosencephaly included alcohol consumption (OR=2.0, 95% C.I. 0.9-4.5), cigarette smoking (OR=4.1, 95% C.I. 1.4-12.0), and combined alcohol and smoking (OR=5.4, 95% C.I. 1.4-20.0), insulin-dependent diabetes (OR=10.2, 95% C.I. 1.9-39.4), medications for respiratory illnesses (OR=2.3, 95% C.I. 0.9-6.0), and salicylate-containing medications (OR=2.5, 95% C.I. 0.8-7.9). "
5.	Insulin (Novolin)FDA Link 02/14/2000 - "Maternal periconceptional exposures associated with increased risks for nonsyndromic holoprosencephaly included alcohol consumption (OR=2.0, 95% C.I. 0.9-4.5), cigarette smoking (OR=4.1, 95% C.I. 1.4-12.0), and combined alcohol and smoking (OR=5.4, 95% C.I. 1.4-20.0), insulin-dependent diabetes (OR=10.2, 95% C.I. 1.9-39.4), medications for respiratory illnesses (OR=2.3, 95% C.I. 0.9-6.0), and salicylate-containing medications (OR=2.5, 95% C.I. 0.8-7.9). "
6.	Folic Acid (Vitamin M)FDA LinkGeneric 04/01/2012 - "The use of periconceptional folic acid or vitamins was not associated with a lower risk of nonsyndromic HPE."