14-O-phosphonooxymethyltriptolide disodium salt

01/01/2016 - "The efficacy of Minnelide, a novel compound which has been shown to be effective against pancreatic cancer in a number of preclinical murine models, was evaluated. "
01/01/2019 - "Minnelide is currently in Phase II clinical trials for treatment of advanced pancreatic cancer, which has fueled increased interest in this promising agent. "
10/17/2012 - "Together, our results suggest that Minnelide shows promise as a potent chemotherapeutic agent against pancreatic cancer, and support the evaluation of Minnelide in clinical trials against this deadly disease."
07/01/2017 - "Inhibition of HSP70 in pancreatic cancer by a novel compound, Minnelide, has shown considerable clinical promise."
01/15/2016 - "Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer."

01/15/2016 - "Furthermore, treatment with Minnelide improved functional vasculature in the tumors resulting in four times more functional vessels in the treated animals compared with untreated animals. "
06/01/2022 - "This trial is designed to determine whether Minnelide can shrink tumors in patients with ASCP who have already received at least one previous treatment for their cancer. "
11/01/2017 - "Minnelide has just completed Phase 1 trial against GI cancers and is currently awaiting Phase 2 trials. "
05/01/2017 - "In vivo, Minnelide (0.21 mg/kg) regressed subcutaneous tumors derived from CRPC 22RV1 at our study endpoint. "
05/01/2014 - "Our study further showed that Minnelide was very efficient in downregulating both CD133(-) and CD133(+) population in the tumors, resulting in a 60% decrease in tumor volume compared with the untreated ones. "

06/01/2015 - "Efficacy of Minnelide was evaluated in subcutaneous xenograft and liver metastasis model of colorectal cancer. "
06/01/2015 - "The aims of the current study were to evaluate whether triptolide/Minnelide is effective against colorectal cancer and to elucidate the mechanism by which triptolide induces cell death in colorectal cancer. "

07/28/2013 - "Minnelide reduces tumor burden in preclinical models of osteosarcoma."
07/28/2013 - "In this study, we have evaluated the preclinical therapeutic efficacy of the novel synthetic drug, Minnelide, a prodrug of triptolide on osteosarcoma. "

11/01/2014 - "The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo. "
11/01/2014 - "The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. "
11/01/2014 - "Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were used to assess the efficacy of Minnelide in inhibiting ovarian cancer growth. "
11/01/2014 - "Minnelide is a promising pro-drug for the treatment of ovarian cancer, especially when combined with standard chemotherapy."