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(S)- 2- (3,4- dimethoxyphenyl)- 1- (5- methoxy- 2,2- dimethyl- 2H- chromen- 6- yl)propan- 1- one

an Hsp90 inhibitor; structure in first source

Also Known As:

SH-1280

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - (S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - (S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one: 1

Experts

1.	An, Hongchan: 1 article (10/2014)
2.	Baek, Yi-Yong: 1 article (10/2014)
3.	Chang, Dong-Jo: 1 article (10/2014)
4.	Cho, Chang Sik: 1 article (10/2014)
5.	Jo, Dong Hyun: 1 article (10/2014)
6.	Jun, Hyoung Oh: 1 article (10/2014)
7.	Kim, Jeong Hun: 1 article (10/2014)
8.	Kim, Jin Hyoung: 1 article (10/2014)
9.	Kim, Kyu-Won: 1 article (10/2014)
10.	Kim, Young-Myeong: 1 article (10/2014)

Related Diseases

1.	Retinal Neovascularization 10/01/2014 - "Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors." 10/01/2014 - "In this study, we demonstrate that destabilization of hypoxia-inducible factor-1α (HIF-1α) by SH-1242 and SH-1280, novel heat shock protein 90 (hsp90) inhibitors, leads to suppression of hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina. "
2.	Hypoxia (Hypoxemia) 10/01/2014 - "Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors." 10/01/2014 - "In this study, we demonstrate that destabilization of hypoxia-inducible factor-1α (HIF-1α) by SH-1242 and SH-1280, novel heat shock protein 90 (hsp90) inhibitors, leads to suppression of hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina. "

Related Drugs and Biologics

1.	Heat-Shock Proteins (Heat-Shock Protein)
2.	2- (3,4- dimethoxyphenyl)- 1- (5- methoxy- 2,2- dimethyl- 2H- chromen- 6- yl)ethanone