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T16AInh-A01

a TMEM16A inhibitor

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - T16AInh-A01: 11
  - Pyrimidines: 510
    - T16AInh-A01: 11
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - T16AInh-A01: 11

Experts

1.	Hollywood, Mark A: 2 articles (11/2017 - 11/2017)
2.	Large, Roddy J: 2 articles (11/2017 - 11/2017)
3.	McHale, Noel G: 2 articles (11/2017 - 11/2017)
4.	Sergeant, Gerard P: 2 articles (11/2017 - 11/2017)
5.	Thornbury, Keith D: 2 articles (11/2017 - 11/2017)
6.	N'Gouemo, Prosper: 1 article (02/2022)
7.	Simms, Mark: 1 article (02/2022)
8.	Thomas, Miracle: 1 article (02/2022)
9.	Chen, Xiao-Shan: 1 article (01/2022)
10.	Chen, Xing-Feng: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Moreover, T16Ainh-A01, a specific TMEM16A inhibitor or shRNA targeting TMEM16A somewhat inhibited lung tumor cell growth and invasion as evident from in vitro studies and from in vivo xenograft-tumor growth. "
2.	Hyperalgesia 06/01/2019 - "These findings were inhibited by T16Ainh-A01 and confirm that TMEM16A plays a key role in persistent chronic constriction injury-induced hyperalgesia. " 10/01/2018 - "Accordingly, repeated (3 times) intrathecal injection of the anoctamin-1 blocker T16Ainh-A01 (0.1-1 µg) or MONNA (1-10 µg) partially reverted SNL-induced mechanical allodynia in a dose-dependent manner. "
3.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 11/01/2017 - "Similarly, spontaneous transient inward currents (STICs) recorded from RUICC voltage clamped at -60 mV and spontaneous transient depolarizations (STDs), recorded in current clamp, were also inhibited by CACCinh-A01 and T16Ainh-A01. "
4.	Seizures (Absence Seizure) 02/15/2022 - "Here we used EACT and T16Ainh-A01, potent activator and inhibitor of calcium-activated channels transmembrane protein 16A (TMEM16A), respectively, to probe the role of these channels in the pathophysiology of acoustically evoked seizures in the GEPR-3s. "
5.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2021 - "Inhibition of ANO1 attenuated the proliferation of HaCaT cells and induced reduction of pERK1/2. Coapplication of IMQ and T16Ainh-A01 on ears of mice reduced not only symptoms of IMQ-induced psoriasis such as thickening and erythema, but also expression of ANO1 and pERK1/2 compared to that of application of IMQ alone. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Anoctamin-1
3.	6- t- butyl- 2- (furan- 2- carboxamido)- 4,5,6,7- tetrahydrobenzo(b)thiophene- 3- carboxylic acid
4.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
5.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
6.	Monocrotaline
7.	Salts
8.	Proteins (Proteins, Gene)
9.	Fibronectins (Fibronectin)
10.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Spinal Injections