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2- N- (6'- (1'- pyridinium)hexanoyl)sphingosine

has antineoplastic activity

Also Known As:

LCL124

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Beckham, Thomas H: 1 article (01/2013)
2.	Beeson, Craig C: 1 article (01/2013)
3.	Beeson, Gyda: 1 article (01/2013)
4.	Bielawska, Alicja: 1 article (01/2013)
5.	Bielawski, Jacek: 1 article (01/2013)
6.	Cheng, Joseph C: 1 article (01/2013)
7.	Drake, Richard R: 1 article (01/2013)
8.	Jones, Elizabeth E: 1 article (01/2013)
9.	Lewis, Clayton S: 1 article (01/2013)
10.	Liu, Xiang: 1 article (01/2013)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2013 - "LCL124 was effective in initiating apoptosis by causing mitochondrial depolarization in pancreatic cancer cells but demonstrated significantly less activity against nonmalignant pancreatic ductal epithelial cells. " 01/01/2013 - "It is noteworthy that gemcitabine-resistant pancreatic cancer cells became more sensitive to subsequent treatment with LCL124, suggesting that this compound may be a uniquely suited to overcome gemcitabine resistance in pancreatic cancer." 01/01/2013 - "LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria." 01/01/2013 - "LCL124 selectively accumulated in and inhibited the growth of xenografts in vivo, confirming the tumor selectivity and therapeutic potential of cationic ceramides in pancreatic cancer. "
2.	Neoplasms (Cancer) 01/01/2013 - "Furthermore, we demonstrate that the mitochondrial membrane potentials of the cancer cells were more negative than nonmalignant cells and that dissipation of this potential abrogated cell killing by LCL124, establishing that the effectiveness of this compound is potential-dependent. " 01/01/2013 - "LCL124 selectively accumulated in and inhibited the growth of xenografts in vivo, confirming the tumor selectivity and therapeutic potential of cationic ceramides in pancreatic cancer. " 01/01/2013 - "Taking advantage of the fact that cancer cells frequently have more negatively charged mitochondria, we investigated a means to circumvent resistance to gemcitabine by targeting delivery of a cationic ceramide (l-t-C6-CCPS [LCL124: ((2S,3S,4E)-2-N-[6'-(1″-pyridinium)-hexanoyl-sphingosine bromide)]) to cancer cell mitochondria. "

Related Drugs and Biologics

1.	Sphingosine
2.	Ceramides
3.	Bromides
4.	Gemcitabine