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LUF6281

partial agonist of nicotinic acid receptor HCA2; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - LUF6281: 1

Experts

1.	Blad, Clara C: 1 article (10/2012)
2.	Hoekstra, Menno: 1 article (10/2012)
3.	Ijzerman, Adriaan P: 1 article (10/2012)
4.	Li, Zhaosha: 1 article (10/2012)
5.	Van Berkel, Theo J C: 1 article (10/2012)
6.	de Vries, Henk: 1 article (10/2012)
7.	van der Sluis, Ronald J: 1 article (10/2012)

Related Diseases

1.

10/01/2012 - "In the current study, we evaluated two partial agonists for HCA(2) , LUF6281 and LUF6283, with respect to their anti-dyslipidaemic potential and cutaneous flushing effect. "
10/01/2012 - "All three compounds reduced plasma VLDL-triglyceride concentrations similarly, while LUF6281 and LUF6283, in contrast to niacin, did not also exhibit the unwanted flushing side effect in C57BL/6 mice. "
10/01/2012 - "The current study identifies LUF6281 and LUF6283, two HCA(2) partial agonists of the pyrazole class, as promising drug candidates to achieve the beneficial lipid lowering effect of niacin without producing the unwanted flushing side effect."

Related Drugs and Biologics

1.	Niacin (Nicotinic Acid)
2.	Lipids
3.	LUF6283
4.	pyrazole
5.	very low density lipoprotein triglyceride