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7-nitro-4-(phenylthio)benzofurazan

has antineoplastic activity; structure in first source

Also Known As:

NBF-SPh

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        7-nitro-4-(phenylthio)benzofurazan: 1

Experts

1.	Baumann, Raymond P: 1 article (10/2012)
2.	Eriksson, Emma S E: 1 article (10/2012)
3.	Eriksson, Leif A: 1 article (10/2012)
4.	Patridge, Eric V: 1 article (10/2012)
5.	Penketh, Philip G: 1 article (10/2012)
6.	Sartorelli, Alan C: 1 article (10/2012)
7.	Shyam, Krishnamurthy: 1 article (10/2012)
8.	Zhu, Rui: 1 article (10/2012)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2012 - "Biochemical and enzymatic assays identified superoxide and hydrogen peroxide as products of its redox-cycling activity, and the rapid rate of ROS production appears to be sufficient to account for some of the toxicity of NBF-SPh (LC(50) = 12.1 μM), possibly explaining why tumor cells exhibit a sharp threshold for tolerating the compound. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	Hydrogen Peroxide (Hydroperoxide)