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1- (4- trifluoromethoxyphenyl)- 3- (4- (5- trifluoromethyl- 2,5- dihydropyrazol- 1- yl)phenyl)urea

has antineoplastic activity; structure in first source

Also Known As:

AW00179

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - 1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-(4-trifluoromethoxyphenyl)-3-(4-(5-trifluoromethyl-2,5-dihydropyrazol-1-yl)phenyl)urea: 1

Experts

1.	Hwang, Mi-Kyung: 1 article (10/2012)
2.	Kim, Seong Hwan: 1 article (10/2012)
3.	Ryu, Byung Jun: 1 article (10/2012)

Related Diseases

1.

Lung Neoplasms (Lung Cancer)

10/01/2012 - "AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules."
10/01/2012 - "In this study, we found that 1-(4-trifluoromethoxy-phenyl)-3-[4-(5-trifluoromethyl-2,5-dihydro-pyrazol-1-yl)-phenyl]-urea (AW00179) sensitized human lung cancer H1299 cells to TRAIL-mediated apoptosis. "

Related Drugs and Biologics

1.	Urea (Carbamide)