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3- (2- mercaptoethyl)biphenyl- 2,3- dicarboxylic acid

inhibits glutamate carboxypeptidase II; structure in first source

Also Known As:

E2072

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Rais, Rana: 2 articles (12/2012 - 12/2012)
2.	Rojas, Camilo: 2 articles (12/2012 - 12/2012)
3.	Slusher, Barbara S: 2 articles (12/2012 - 12/2012)
4.	Tsukamoto, Takashi: 2 articles (12/2012 - 12/2012)
5.	Alt, Jesse: 1 article (12/2012)
6.	Hoover, Randall: 1 article (12/2012)
7.	Lapidus, Rena: 1 article (12/2012)
8.	Rudek, Michelle A: 1 article (12/2012)
9.	Vornov, James J: 1 article (12/2012)
10.	Wozniak, Krystyna: 1 article (12/2012)

Related Diseases

1.	Pain (Aches) 12/01/2012 - "The observed long exposures were consistent with the sustained efficacy of E2072 in rodent pain models for several days after dose cessation. "
2.	Leukemia L1210 12/01/2012 - "It is noteworthy that E2072 showed no interference with the antineoplastic efficacy of oxaliplatin in mice bearing leukemia (L1210), even at doses 100 times its neuroprotective/analgesic dose, indicating a selective effect on neuropathy. "
3.	Peripheral Nervous System Diseases (PNS Diseases) 12/01/2012 - "The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy." 12/01/2012 - "E2072 [(3-2-mercaptoethyl)biphenyl-2,3'-dicarboxylic acid] is a novel, potent and selective thiol-based glutamate carboxypeptidase II (GCP-II) inhibitor that has shown robust analgesic and neuroprotective efficacy in preclinical models of neuropathic pain and chemotherapy-induced peripheral neuropathy. "
4.	Neuralgia (Stump Neuralgia) 12/01/2012 - "Here, we report that E2072 attenuates hyperalgesia and nerve conduction velocity deficits in preclinical rodent models of neuropathic pain and oxaliplatin-induced neuropathy. " 12/01/2012 - "E2072 [(3-2-mercaptoethyl)biphenyl-2,3'-dicarboxylic acid] is a novel, potent and selective thiol-based glutamate carboxypeptidase II (GCP-II) inhibitor that has shown robust analgesic and neuroprotective efficacy in preclinical models of neuropathic pain and chemotherapy-induced peripheral neuropathy. "
5.	Hyperalgesia 12/01/2012 - "In the chronic constrictive injury model, orally administered E2072 reversed pre-existing thermal hyperalgesia in rats in a dose-dependent fashion with a minimally effective dose of 0.1 mg/kg/day. " 12/01/2012 - "Here, we report that E2072 attenuates hyperalgesia and nerve conduction velocity deficits in preclinical rodent models of neuropathic pain and oxaliplatin-induced neuropathy. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Antineoplastic Agents (Antineoplastics)
3.	Oxaliplatin (Eloxatin)
4.	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)
5.	Sulfhydryl Compounds (Thiols)
6.	Acids
7.	diphenyl (biphenyl)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)