7-(O)-carboxymethyl daidzein N-t-Boc-hexylenediamine conjugate

has antineoplastic activity

Also Known As:

5-(25)-pentyl-carbamic acid tert-butyl ester N-t-Boc-7-(O)-carboxymethyl daidzein; 5-(25)-pentyl-carbamic acid tert-butyl ester N-tert-butoxycarbonyl-7-(O)-carboxymethyl daidzein; Cd-tBoc; carboxy-daidzein-tBoc

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        7-(O)-carboxymethyl daidzein N-t-Boc-hexylenediamine conjugate: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        7-(O)-carboxymethyl daidzein N-t-Boc-hexylenediamine conjugate: 4

Experts

1.	Kohen, Fortune: 3 articles (01/2018 - 08/2012)
2.	Somjen, Dalia: 3 articles (01/2018 - 08/2012)
3.	Stern, Naftali: 3 articles (01/2018 - 08/2012)
4.	Izkhakov, Elena: 2 articles (01/2018 - 08/2012)
5.	Sharon, Orli: 2 articles (01/2018 - 08/2012)
6.	Grafi-Cohen, Meital: 2 articles (11/2012 - 08/2012)
7.	Aizic, Asaf: 1 article (01/2018)
8.	Fliss, Dan M: 1 article (01/2018)
9.	Knoll, Esther: 1 article (01/2018)
10.	Greenman, Yona: 1 article (11/2012)

Related Diseases

1.	Goiter 08/01/2012 - "This study provides the first evidence that cD-tboc can act to inhibit growth in primary cultures of human PTC cells and goiter cells removed during thyroidectomy. " 08/01/2012 - "Third, cD-tboc dose-dependently inhibited DNA synthesis in cultured human PTC cells (-65%) and to a lesser extent in goiter cells (∼-30%). " 08/01/2012 - "Here we tested the hypothesis that cD-tboc can likewise retard cell growth in cultured human thyroid papillary carcinoma cells, normal thyroid cells, and goiter cells removed during thyroidectomy. "
2.	Thyroid Neoplasms (Thyroid Cancer) 09/01/2011 - "These results suggest that cD-tboc may be a promising agent for therapy of thyroid carcinoma either alone or in combination with existing cytotoxic drugs." 09/01/2011 - "Here, we explore whether or not human thyroid cancer cell growth can be curbed by a novel isoflavone derivative generated in our laboratory, the N-t-Boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc). " 01/01/2018 - "Our group recently reported that isoflavone derivative 7-(O)-carboxymethyl daidzein conjugated to N-t-boc-hexylenediamine (cD-tboc), a novel anti-estrogenic compound, retards the growth of both thyroid carcinoma cell lines and cultured human carcinoma cells. " 08/01/2012 - "We have recently reported that a novel isoflavone-derived anti-estrogenic compound developed in our laboratory, the N-t-boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc), can induce apoptosis and retard growth in human thyroid carcinoma cell lines through inhibitory interaction on estrogen receptor β. "
3.	Neoplasms (Cancer) 09/01/2011 - "When nude mice carrying ARO thyroid xenografts were treated with cD-tboc, tumor volume decreased significantly, and no apparent toxicity was observed. " 11/01/2012 - "In view of the possible role of estrogen in the development of thyroid neoplasia, we explored whether proliferation of the human MTC TT cell line, might be curbed by carboxy-daidzein-tBoc (cD-tBoc), a novel isoflavone derivative. "
4.	Necrosis 11/01/2012 - "Furthermore, cD-tBoc potently increased apoptosis and cell necrosis. " 09/01/2011 - "By contrast, cD-tboc, derived from the weak estrogen daidzein, did not cause cell growth and dose-dependently diminished cell growth in all four cell lines via apoptosis and not necrosis, as detected by the release of histone-DNA fragments. "
5.	Papillary Carcinoma 08/01/2012 - "Here we tested the hypothesis that cD-tboc can likewise retard cell growth in cultured human thyroid papillary carcinoma cells, normal thyroid cells, and goiter cells removed during thyroidectomy. "

Related Drugs and Biologics

1.	Isoflavones
2.	daidzein
3.	Estrogens (Estrogen)
4.	DNA (Deoxyribonucleic Acid)
5.	7-(O)-carboxymethyl daidzein N-t-Boc-hexylenediamine conjugate
6.	Estrogen Receptors
7.	Histones (Histone)

Related Therapies and Procedures

1.	Thyroidectomy
2.	Therapeutics