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4- (2- (1,1- dioxido- 6- (2,4,6- trichlorophenyl)- 1,2,6- thiadiazinan- 2- yl)acetamido)adamantane- 1- carboxamide

has both antidiabetic and anti-adipogenic activities; structure in first source

Also Known As:

KR-67183

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        4-(2-(1,1-dioxido-6-(2,4,6-trichlorophenyl)-1,2,6-thiadiazinan-2-yl)acetamido)adamantane-1-carboxamide: 1
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        4-(2-(1,1-dioxido-6-(2,4,6-trichlorophenyl)-1,2,6-thiadiazinan-2-yl)acetamido)adamantane-1-carboxamide: 1
- Sulfur Compounds: 278
  - Thiazines: 3
    - Thiadiazines: 4
      - 4-(2-(1,1-dioxido-6-(2,4,6-trichlorophenyl)-1,2,6-thiadiazinan-2-yl)acetamido)adamantane-1-carboxamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - Thiadiazines: 4
      - 4-(2-(1,1-dioxido-6-(2,4,6-trichlorophenyl)-1,2,6-thiadiazinan-2-yl)acetamido)adamantane-1-carboxamide: 1

Experts

1.	Ahn, Jin Hee: 1 article (09/2012)
2.	Jung, Won Hoon: 1 article (09/2012)
3.	Kang, Nam Sook: 1 article (09/2012)
4.	Kang, Seung Kyu: 1 article (09/2012)
5.	Kim, Hee Youn: 1 article (09/2012)
6.	Kim, Ki Young: 1 article (09/2012)
7.	Park, Ji Seon: 1 article (09/2012)
8.	Rhee, Sang Dal: 1 article (09/2012)

Related Diseases

1.	Insulin Resistance 09/15/2012 - "In the study with DIO mice, the administration of KR-67183 (20 and 50mg/kg/day, orally for 28 days) improved the glucose tolerance and insulin sensitivity with suppressed 11β-HSD1 activity in the liver and fat. "
2.	Obesity 09/15/2012 - "Taken together, it is suggested that a selective 11β-HSD1 inhibitor, KR-67183, may provide a new therapeutic window in the prevention and treatment without toxicity in type 2 diabetes with obesity."
3.	Type 2 Diabetes Mellitus (MODY) 09/15/2012 - "Taken together, it is suggested that a selective 11β-HSD1 inhibitor, KR-67183, may provide a new therapeutic window in the prevention and treatment without toxicity in type 2 diabetes with obesity."
4.	Body Weight (Weight, Body) 09/15/2012 - "However, KR-67183 showed no change in the adrenal gland weight/body weight ratio and plasma corticosterone concentration in DIO mice. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Corticosterone