2- (4- ethylpiperazin- 1- yl)- N- (4- (2- morpholino- 4- oxo- 4H- chromen- 8- yl)dibenzo(b,d)thiophen- 1- yl)acetamide

structure in first source

Also Known As:

KU-0060648

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo(b,d)thiophen-1-yl)acetamide: 3
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo(b,d)thiophen-1-yl)acetamide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo(b,d)thiophen-1-yl)acetamide: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo(b,d)thiophen-1-yl)acetamide: 3

Experts

1.	Gao, Xinhai: 1 article (01/2017)
2.	Liu, Yumei: 1 article (01/2017)
3.	Mao, Mintao: 1 article (01/2017)
4.	Chen, Gang: 1 article (03/2016)
5.	Chen, Min-Bin: 1 article (03/2016)
6.	Lu, Pei-Hua: 1 article (03/2016)
7.	Ruan, Ting-Yan: 1 article (03/2016)
8.	Tang, Min: 1 article (03/2016)
9.	Wei, Mu-Xin: 1 article (03/2016)
10.	Xu, Jun-Ying: 1 article (03/2016)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2017 - "Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells." 01/01/2017 - "The current study evaluated the potential anti-colorectal cancer (CRC) activity by Ku-0060648, a novel DNA-PKcs and PI3K duel inhibitor. "
2.	Neoplasms (Cancer) 08/01/2012 - "In mice bearing SW620 and MCF7 xenografts, concentrations of KU-0060648 that were sufficient for in vitro growth inhibition and chemosensitization were maintained within the tumor for at least 4 hours at nontoxic doses. " 03/29/2016 - "Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. " 08/01/2012 - "KU-0060648 alone delayed the growth of MCF7 xenografts and increased etoposide-induced tumor growth delay in both in SW620 and MCF7 xenografts by up to 4.5-fold, without exacerbating etoposide toxicity to unacceptable levels. " 08/01/2012 - "Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K."
3.	Colonic Neoplasms (Colon Cancer) 01/01/2017 - "In both CRC cell lines (HCT-116 and HT-29) and primary human colon cancer cells, Ku-0060648 exposure at nM concentrations efficiently inhibited cell proliferation. " 08/01/2012 - "KU-0060648 was investigated in a panel of human breast and colon cancer cells. "
4.	Hepatocellular Carcinoma (Hepatoma) 03/29/2016 - "Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. " 03/29/2016 - "KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
3.	Phosphatidylinositol 3-Kinases (PI 3 Kinase)
4.	Etoposide (VP 16)