morusinol

11/01/2023 - "The experiments in animal models also showed that morusinol significantly impeded tumor growth in mice models. "
06/01/2023 - "However, the anti-cancer mechanism of morusinol remains unclear. "
06/01/2023 - "In present study, we mainly studied the anti-tumor effect of morusinol and its mode of action in melanoma. "
12/01/2019 - "RESULTS Morusinol inhibited the proliferation of liver cancer SK-HEP-1 cells, with an IC₅₀ of 20 µM against the SK-HEP-1liver cancer cells. "
12/01/2019 - "Morusinol also suppressed the migration and invasion of SK-HEP-1liver cancer cells, and it suppressed the expression of p-MEK and p-ERK, leading to suppression of the Raf/MEK/ERK signalling cascade. "

01/01/2012 - "Taken together, these results indicate that morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity. "
01/01/2012 - "Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease."
01/01/2012 - "Thrombus formation was reduced by 32.1, 42.0, and 99.0% for collagen-induced TXB(2) formation, and 8.0, 24.1, and 29.2% for arachadonic acid-induced TXB(2) formation, with 5, 10, and 30 µg/mL morusinol, respectively. "
01/01/2012 - "This study further evaluated the effects of morusinol, a flavonoid derived from Morus alba root bark, on platelet aggregation and thromboxane B(2) (TXB(2) formation in vitro and thrombus formation in vivo. "

06/01/2023 - "Whereafter, morusinol-induced cell cycle arrest, apoptosis and DNA damage were partially salvaged by overexpressing CHK1 in melanoma cell lines. "
06/01/2023 - "In addition, morusinol effectively inhibited the growth of melanoma xenografts in vivo. "
06/01/2023 - "We demonstrated that morusinol not only had the ability to inhibit cell proliferation, but also induced cell cycle arrest at G0/G1 phase, caspase-dependent apoptosis and DNA damage in human melanoma cells. "
06/01/2023 - "In present study, we mainly studied the anti-tumor effect of morusinol and its mode of action in melanoma. "
06/01/2023 - "Herein, further experiments demonstrated that morusinol increased the sensitivity of dacarbazine (DTIC) to chemotherapy for melanoma in vitro and in vivo. "

12/01/2019 - "Against this background, in this study we evaluated the anticancer activity of morusinol against SK-HEP-1 liver cancer cells. "
12/01/2019 - "CONCLUSIONS We found that morusinol exerts significant anticancer and autophagic effects on liver cancer cells and our results suggest the potential of morusinol in treatment of liver cancer."
12/01/2019 - "RESULTS Morusinol inhibited the proliferation of liver cancer SK-HEP-1 cells, with an IC₅₀ of 20 µM against the SK-HEP-1liver cancer cells. "

03/25/2021 - "Reference: Zhen Zhu, Tianyu Xiao, Xuejiao Chang, Yanfei Hua, Jinli Gao: Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway. "
03/25/2021 - "Retracted: Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway."
12/01/2019 - "Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway."