cibinetide

a synthetic 11-mer peptide that binds the tissue-protective receptor

Also Known As:

ARA-290; ARA290; UEQLERALNSS; pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser; pHBSP peptide; pyroglutamate helix B surface peptide; pyroglutamate-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serine

Networked: 35 relevant articles (9 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - cibinetide: 35

Experts

1.	Brines, Michael: 18 articles (10/2020 - 09/2011)
2.	Cerami, Anthony: 15 articles (10/2020 - 07/2011)
3.	Dahan, Albert: 6 articles (01/2018 - 11/2011)
4.	van Velzen, Monique: 4 articles (01/2018 - 02/2014)
5.	Niesters, Marieke: 4 articles (07/2016 - 11/2011)
6.	Dunne, Ann: 3 articles (07/2020 - 01/2013)
7.	Collino, Massimo: 3 articles (02/2018 - 09/2011)
8.	Tannemaat, Martijn R: 3 articles (01/2018 - 01/2015)
9.	Yarmush, Martin L: 3 articles (10/2017 - 02/2013)
10.	Aarts, Leon: 3 articles (02/2014 - 11/2011)

Related Diseases

1.	Sarcoidosis (Schaumann Disease) 07/01/2016 - "In patients with sarcoidosis, ARA290 significantly improved neuropathic and autonomic symptoms, as well as quality of life as assessed by the small fiber neuropathy screening list questionnaire. " 01/01/2018 - "We have compared the utility of the standard CCM variables employed to CNF size in patients with diabetic sensorimotor polyneuropathy or sarcoidosis-associated SFN, and in patients with SFN following cibinetide administration, an agent which promotes nerve repair. " 01/01/2017 - "Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain." 07/01/2016 - "In humans, ARA290 has been evaluated in patients with small fiber neuropathy associated with sarcoidosis or type 2 diabetes (T2D) mellitus. " 01/01/2015 - "Whether the intravenous administration of immunoglobulins or ARA290, an erythropoietin derivative with TNF-α-antagonistic and tissue-protective characteristics, is effective for small nerve fibre neuropathy in sarcoidosis is subject for study."
2.	Ischemia 01/09/2013 - "The improvement in renal function following renal ischemia/reperfusion and reduced structural damage observed in this study by ARA290 warrants further investigation towards clinical application." 10/01/2016 - "This work aims to investigate the effects of ARA290, a specific agonist of EPOR/CD131 complex, on a subpopulation of endothelial progenitor cells named endothelial colony-forming cells (ECFCs) and to characterize its contribution to ECFCs-induced angiogenesis after peripheral ischemia. " 11/13/2013 - "ARA290 is renoprotective in renal ischemia/reperfusion (I/R). " 10/01/2016 - "We injected ARA290 to mice undergoing chronic hindlimb ischemia (CLI) in combination with ECFC transplantation. " 01/01/2019 - "Efficacy of ECFC transplantation therapy to promote retinal vascular repair in the presence and absence of ARA290 was studied in the oxygen induced retinopathy (OIR) model of retinal ischemia. "
3.	Neuralgia (Stump Neuralgia) 03/13/2013 - "In summary, ARA290 may be beneficial in the treatment of neuropathic pain symptoms where signs of nerve injury are absent on clinical assessment. " 11/01/2011 - "It is argued that relief of neuropathic pain attributable to ARA290 treatment is related to its antiinflammatory properties, possibly within the central nervous system. " 01/01/2017 - "Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain." 01/01/2017 - "This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity (6-minute walk test [6MWT]). " 11/01/2011 - "Because ARA290, in contrast to erythropoietin, is devoid of hematopoietic and cardiovascular side effects, ARA290 is a promising new drug in the prevention of peripheral nerve injury-induced neuropathic pain in humans."
4.	Inflammation (Inflammations) 10/01/2021 - "Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a combination of these mechanisms. " 08/01/2020 - "ARA290 markedly attenuated DOX induced oxidative stress and protected against DOX induced inflammation and apoptotic cell death. " 10/01/2020 - "Cibinetide reduced the initial transplantation-related severe inflammation and delayed the subsequent alloreactivity. " 03/15/2014 - "In summary, our study here showed that ARA290 could alter T cell function to suppress inflammation to ameliorate EAE, suggesting that ARA290 may be a new therapeutic candidate for multiple sclerosis." 01/01/2022 - "Administration of ARA290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan."
5.	Hyperalgesia 11/01/2011 - "ARA290 was effective in wild-type mice, producing significant relief of allodynia. " 07/01/2016 - "After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in animals with a β-common receptor knockout phenotype. " 02/16/2014 - "ARA290 exerted a dose-response effect by significantly reducing mechanical allodynia up to 20 weeks when compared to vehicle. " 03/13/2013 - "However, ARA290 did not significantly affect heat hyperalgesia. " 03/13/2013 - "Treatment with either 30 (n=11) or 120 μg/kg ARA290 (n=9) prevented the development of mechanical allodynia. "

Related Drugs and Biologics

1.	Erythropoietin
2.	Peptides (Polypeptides)
3.	Immunoglobulins (Immunoglobulin)
4.	Retinaldehyde (Retinal)
5.	Oxygen (Dioxygen)
6.	Biomarkers (Surrogate Marker)
7.	Amino Acids
8.	Ligands
9.	cibinetide
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Intravenous Administration
2.	Transplantation
3.	Therapeutics
4.	Transjugular Intrahepatic Portasystemic Shunt
5.	Intraperitoneal Injections