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CKGGRAKDC-GG-D(KLAKLAK)2

designed to induce apoptosis of endothelium in white adipose tissue (WAT), decreases adiposity

Also Known As:

adipotide; proapoptotic peptide (HF-PP)

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - CKGGRAKDC-GG-D(KLAKLAK)2: 3
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - CKGGRAKDC-GG-D(KLAKLAK)2: 3
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - CKGGRAKDC-GG-D(KLAKLAK)2: 3

Experts

1.	Akita, Hidetaka: 1 article (10/2013)
2.	Harashima, Hideyoshi: 1 article (10/2013)
3.	Hossen, Nazir: 1 article (10/2013)
4.	Hyodo, Mamoru: 1 article (10/2013)
5.	Kajimoto, Kazuaki: 1 article (10/2013)
6.	Criscione, Leoluca: 1 article (04/2012)
7.	Arap, Wadih: 1 article (11/2011)
8.	Barnhart, Kirstin F: 1 article (11/2011)
9.	Baze, Wallace B: 1 article (11/2011)
10.	Bernacky, Bruce J: 1 article (11/2011)

Related Diseases

1.	Weight Loss (Weight Reduction) 11/09/2011 - "Treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss and improved insulin resistance in obese monkeys. " 04/25/2012 - "A study reporting that a peptidomimetic adipotide reduces weight loss in obese monkeys by inducing apoptosis of blood vessels surrounding white adipose tissue may instead reflect a direct effect of adipotide on food consumption."
2.	Insulin Resistance 11/09/2011 - "Treatment with adipotide induced targeted apoptosis within blood vessels of white adipose tissue and resulted in rapid weight loss and improved insulin resistance in obese monkeys. "
3.	Obesity 11/09/2011 - "Together, these data in primates establish adipotide as a prototype in a new class of candidate drugs that may be useful for treating obesity in humans."
4.	Body Weight (Weight, Body) 10/28/2013 - "The systemic injection of DIO mice with a low dose of KLA-PTNP, rather than a bioconjugate composed of the same targeting peptide and KLA (Adipotide) resulted in a reduction in body weight, as evidenced by a significant decrease in serum leptin levels, in parallel with an antiobesity effect on dysfunctional adipose cells, including adipocytes and macrophages. "

Related Drugs and Biologics

1.	Peptidomimetics
2.	Leptin
3.	Peptides (Polypeptides)