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IC486241

a DNA-dependent protein kinase inhibitor

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Acridones: 26
    - IC486241: 1
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Acridones: 26
        IC486241: 1

Experts

1.	Aloyz, Raquel: 1 article (08/2012)
2.	Amrein, Lilian: 1 article (08/2012)
3.	Davidson, David: 1 article (08/2012)
4.	Grenier, Jeremy: 1 article (08/2012)
5.	Martinez-Marignac, Veronica: 1 article (08/2012)
6.	Panasci, Lawrence: 1 article (08/2012)
7.	Shawi, May: 1 article (08/2012)
8.	Tokars, Marc: 1 article (08/2012)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

08/01/2012 - "The purpose of this study was to determine the degree to which the novel DNA-PKcs inhibitor, IC486241 (ICC), synergizes the cytotoxicity of DNA damaging agents in 3 genetically diverse breast cancer cell lines. "
08/01/2012 - "Effects of the novel DNA dependent protein kinase inhibitor, IC486241, on the DNA damage response to doxorubicin and cisplatin in breast cancer cells."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
3.	DNA-Activated Protein Kinase
4.	Doxorubicin (Adriamycin)
5.	Cisplatin (Platino)