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A-960656

a histamine H3 receptor antagonist; structure in first source

Also Known As:

(R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo(d)thiazol-6-yl)pyridazin-3(2H)-one hemihydrate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        A-960656: 3
  - Pyridazines: 11
    - A-960656: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - A-960656: 3

Experts

1.	Pertovaara, Antti: 2 articles (02/2016 - 12/2014)
2.	Viisanen, Hanna: 2 articles (02/2016 - 12/2014)
3.	Wei, Hong: 2 articles (02/2016 - 12/2014)
4.	You, Hao-Jun: 2 articles (02/2016 - 12/2014)
5.	Jin, Cong-Yu: 1 article (12/2014)
6.	Black, Lawrence A: 1 article (06/2012)
7.	Brioni, Jorge D: 1 article (06/2012)
8.	Carr, Tracy: 1 article (06/2012)
9.	Cowart, Marlon: 1 article (06/2012)
10.	Diaz, Gilbert: 1 article (06/2012)

Related Diseases

1.	Pain (Aches) 06/05/2012 - "In summary, A-960656 has properties well suited to probe the pharmacology of histamine H(3) receptors in pain. " 06/05/2012 - "In a spinal nerve ligation model of neuropathic pain in rat, oral doses of 1 and 3mg/kg were effective 60 min post dosing with an ED(50) of 2.17 mg/kg and a blood EC(50) of 639 ng/ml. In a model of osteoarthritis pain, oral doses of 0.1, 0.3, and 1mg/kg were effective 1h post dosing with an ED(50) of 0.52 mg/kg and a blood EC(50) of 233 ng/ml. The antinociceptive effect of A-960656 in both pain models was maintained after sub-chronic dosing up to 12 days. " 12/01/2014 - "Zolantidine or pyrilamine alone in the LC failed to influence pain behavior, while A-960656 (histamine H3 receptor antagonist) suppressed hypersensitivity. "
2.	Hypersensitivity (Allergy) 02/05/2016 - "A-960656, a histamine H3 receptor antagonist alone that presumably increased endogenous histamine levels reduced hypersensitivity. " 12/01/2014 - "Zolantidine or pyrilamine alone in the LC failed to influence pain behavior, while A-960656 (histamine H3 receptor antagonist) suppressed hypersensitivity. "
3.	Osteoarthritis 06/05/2012 - "Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain." 06/05/2012 - "In a spinal nerve ligation model of neuropathic pain in rat, oral doses of 1 and 3mg/kg were effective 60 min post dosing with an ED(50) of 2.17 mg/kg and a blood EC(50) of 639 ng/ml. In a model of osteoarthritis pain, oral doses of 0.1, 0.3, and 1mg/kg were effective 1h post dosing with an ED(50) of 0.52 mg/kg and a blood EC(50) of 233 ng/ml. The antinociceptive effect of A-960656 in both pain models was maintained after sub-chronic dosing up to 12 days. "
4.	Neuralgia (Stump Neuralgia) 06/05/2012 - "Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain." 06/05/2012 - "In a spinal nerve ligation model of neuropathic pain in rat, oral doses of 1 and 3mg/kg were effective 60 min post dosing with an ED(50) of 2.17 mg/kg and a blood EC(50) of 639 ng/ml. In a model of osteoarthritis pain, oral doses of 0.1, 0.3, and 1mg/kg were effective 1h post dosing with an ED(50) of 0.52 mg/kg and a blood EC(50) of 233 ng/ml. The antinociceptive effect of A-960656 in both pain models was maintained after sub-chronic dosing up to 12 days. "

Related Drugs and Biologics

1.	Histamine H3 Receptors (Histamine H3 Receptor)
2.	Histamine (Histamine Dihydrochloride)
3.	Pyrilamine (Mepyramine)
4.	zolantidine

Related Therapies and Procedures

1.	Ligation