N- (7- (1- hydroxyethyl)- 3- (4- isopropylphenyl)- 4,6- dimethyl- 2,3- dihydro- 1- benzofuran- 5- yl)- 3,3- dimethylbutanamide

01/01/2012 - "In a previous study, TAK-937, a novel potent and selective CB(1) and CB(2) receptor agonist, was shown to exert significant cerebroprotective effects accompanied by hypothermia after transient middle cerebral artery occlusion (MCAO) in rats. "
08/14/2013 - "Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle cerebral artery occlusion (MCAO) model and conducted a combination study with TAK-937 and tissue type plasminogen activator (t-PA) in a rat thrombotic MCAO model. "

01/01/2012 - "In the present studies, we examined the relative contribution of hypothermia and CB(1) receptor activation to the cerebroprotective effects of TAK-937. "
01/01/2012 - "We conclude that the cerebroprotective effects of TAK-937 were at least in part mediated by induction of hypothermia, and mainly mediated by CB(1) receptor activation."
01/01/2012 - "In a previous study, TAK-937, a novel potent and selective CB(1) and CB(2) receptor agonist, was shown to exert significant cerebroprotective effects accompanied by hypothermia after transient middle cerebral artery occlusion (MCAO) in rats. "
01/01/2012 - "Contribution of hypothermia and CB1 receptor activation to protective effects of TAK-937, a cannabinoid receptor agonist, in rat transient MCAO model."

08/14/2013 - "TAK-937 reduced infarct volume of aged rats as well, when it was administered 1h after permanent MCAO. "
08/14/2013 - "TAK-937 significantly reduced infarct volume when it was administered 3 and 5h after permanent MCAO in young adult rats. "
01/09/2012 - "In the monkey thromboembolic MCAo model, TAK-937 showed trend to reduce the infarct volume and S-100ß levels in CSF by 40%. "
01/01/2012 - "When the hypothermic effect of TAK-937 was completely reversed by a brain temperature controlling system, the infarct-reducing effect of TAK-937 was attenuated in part, but remained significant. "
01/09/2012 - "In the rat t-MCAo model, TAK-937 significantly reduced the infarct volume in male, female and ovariectomized rats and also improved functional outcomes and brain atrophy. "

01/09/2012 - "In the rat t-MCAo model, TAK-937 significantly reduced the infarct volume in male, female and ovariectomized rats and also improved functional outcomes and brain atrophy. "

01/09/2012 - "In this study, the effect of TAK-937 on ischemic brain damage was examined in rat and monkey ischemic stroke models. "
01/09/2012 - "These results suggest that TAK-937 may be useful for treatment of acute ischemic stroke. "