3,5- bis(2- pyridinylmethylidene)- 4- piperidone

06/01/2012 - "The long term effect of EF31 on the NF-κB signaling system in the tumors was examined by Western blot analysis. "
02/01/2012 - "Finally, EF31 demonstrated potent toxicity in NF-κB-dependent cancer cell lines while having minimal and reversible toxicity in RAW264.7 macrophages. "
06/01/2012 - "Human head and neck squamous cell carcinoma Tu212 xenograft tumors were established in athymic nude mice and treated with EF31 i.p. "
04/10/2016 - "EF31 and UBS109 treatment significantly decreased tumor growth in compared to untreated tumors. "
12/01/2013 - "Similar results were observed in vitro when subcutaneous tumors (MiaPaCa-2) were treated with EF31 and UBS109. "

01/01/2017 - "Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer."
02/28/2015 - "We hypothesized that curcumin and its analogues EF31 and UBS109 would disrupt angiogenesis in pancreatic cancer (PC) through modulation of HIF-1α and NF-κB. "
12/01/2013 - "Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer."

04/10/2016 - "We tested the hypothesis that inhibition of NF-κB translocation by curcumin and its analogs EF31 and UBS109 can inhibit cell cycle progression and downregulate TS levels in colorectal cancer (CRC) cell lines. "

06/01/2012 - "The long term EF31 treatment inhibited NF-κB p65 phosphorylation in xenografts, implicating downregulation of cancer promoting transcription factors such as angiogenesis and metastasis."

06/01/2012 - "Human head and neck squamous cell carcinoma Tu212 xenograft tumors were established in athymic nude mice and treated with EF31 i.p. "
06/01/2012 - "Objectives are to examine the efficacy, pharmacokinetics, and toxicology of a synthetic curcumin analog EF31 in head and neck squamous cell carcinoma. "
06/01/2012 - "Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts."
06/01/2012 - "In conclusion, the novel synthetic curcumin analog EF31 is efficacious in inhibiting the growth of Tu212 xenograft tumors and may be useful for treating head and neck squamous cell carcinoma. "