nor-beta-lapachone

has antineoplastic activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Ferreira, Vitor F: 2 articles (08/2008 - 11/2007)
2.	Pinto, Antônio V: 2 articles (08/2008 - 11/2007)
3.	Pinto, Maria do Carmo F R: 2 articles (08/2008 - 11/2007)
4.	de Souza, Maria Cecília B V: 2 articles (08/2008 - 11/2007)
5.	De Castro, Solange L: 1 article (08/2008)
6.	De Simone, Carlos Alberto: 1 article (08/2008)
7.	Menna-Barreto, Rubem F S: 1 article (08/2008)
8.	Silva, Raphael S F: 1 article (08/2008)
9.	Teixeira, Daniel V: 1 article (08/2008)
10.	da Silva, Eufrânio N: 1 article (08/2008)

1.	Chagas Disease (American Trypanosomiasis) 08/01/2008 - "These triazole derivatives of nor-beta-lapachone emerge as interesting new lead compounds in drug development for Chagas disease." 08/01/2008 - "[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. "
2.	Neoplasms (Cancer) 11/15/2007 - "Several arylamino derivatives of nor-beta-lapachone were synthesized in moderate to high yields and found to show very potent cytotoxicity against six neoplastic cancer cells: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (breast), HL-60 (leukaemia), PC-3 (prostate), and B-16 (murine melanoma), with IC(50) below 1 microg/mL. Their cytotoxicities were compared to doxorubicin and with their synthetic precursors, beta-lapachone and nor-beta-lapachone. "
3.	Melanoma (Melanoma, Malignant) 11/15/2007 - "Several arylamino derivatives of nor-beta-lapachone were synthesized in moderate to high yields and found to show very potent cytotoxicity against six neoplastic cancer cells: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (breast), HL-60 (leukaemia), PC-3 (prostate), and B-16 (murine melanoma), with IC(50) below 1 microg/mL. Their cytotoxicities were compared to doxorubicin and with their synthetic precursors, beta-lapachone and nor-beta-lapachone. "