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1- O- hexadecyl- 2- O- methylglycero- 3- lactose

a SK3 channel inhibitor

Also Known As:

1-O-hexadecyl-2-O-methyl-sn-glycero-3-lactose; Ohmline

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycolipids: 2799
    - 1-O-hexadecyl-2-O-methylglycero-3-lactose: 8
Lipids: 114793
- Glycolipids: 2799
  - 1-O-hexadecyl-2-O-methylglycero-3-lactose: 8

Experts

1.	Vandier, Christophe: 6 articles (01/2021 - 08/2013)
2.	Chantôme, Aurélie: 5 articles (01/2021 - 08/2013)
3.	Potier-Cartereau, Marie: 5 articles (07/2020 - 08/2013)
4.	Jaffrès, Paul-Alain: 4 articles (01/2021 - 08/2013)
5.	Guéguinou, Maxime: 3 articles (07/2020 - 08/2013)
6.	Bougnoux, Philippe: 3 articles (06/2016 - 08/2013)
7.	Couthon, Hélène: 2 articles (01/2021 - 10/2017)
8.	Fromont, Gaëlle: 2 articles (07/2020 - 08/2013)
9.	Besson, Pierre: 2 articles (01/2016 - 08/2013)
10.	Bauduin, Alicia: 1 article (01/2021)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 06/14/2016 - "This study demonstrates that the inhibition of the SOCE-dependent colon cancer cell migration trough SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a novel strategy to modulate Anti-EGFR mAb action in mCRC." 06/14/2016 - "SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline."
2.	Neoplasms (Cancer) 01/01/2021 - "Among the three Ohmline Pyrene compounds (OP1-3) only OP2 is able to reduce SK3 currents and is the first efficient fluorescent modulator of SK3 channel as revealed by patch clamp measurements (- 71.3 ± 13.3% at 10 μM) and by its inhibition of SK3-dependent cancer cell migration at (-32.5% ± 4.8% at 1 μM). " 11/01/2011 - "Finally, Ohmline reduced metastasis development in a mice model of tumor indicating that this compound could become a lead compound for the first class of lipid-antimetastatic agent." 10/31/2017 - "SK3 channels are abnormaly expressed in metastatic cells, and Ohmline (OHM), an ether lipid, has been shown to reduce the activity of SK3 channels and the migration capacity of cancer cells. " 01/01/2016 - "Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β-lactose), are forming a class of antitumor agents that target cell membranes to induce apoptosis and to decrease cell migration/invasion, leading to the inhibition of tumor and metastasis development. "
3.	Neoplasm Metastasis (Metastasis) 08/01/2013 - "Upon Ohmline treatment, the SK3-Orai1 complex moved away from lipid rafts, and SK3-dependent Ca(2+) entry, migration, and bone metastases were subsequently impaired. " 11/01/2011 - "Finally, Ohmline reduced metastasis development in a mice model of tumor indicating that this compound could become a lead compound for the first class of lipid-antimetastatic agent." 01/01/2023 - "More recently, ohmline, a glyco glycero ether lipid that modulates selectively SK3 ion channels and reduces in vivo the occurrence of bone metastases, and other glyco glycero ether also identified as GAEL (glycosylated antitumor ether lipids) that exhibit promising anticancer properties renew the interest in this class of compounds. " 01/01/2016 - "Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β-lactose), are forming a class of antitumor agents that target cell membranes to induce apoptosis and to decrease cell migration/invasion, leading to the inhibition of tumor and metastasis development. "
4.	Hypoxia (Hypoxemia) 07/06/2020 - "Taking into account the sensitivity of the SK3 channel to the membrane lipid composition, we identified lipids such as Ohmline (an alkyl ether lipid and SK3 inhibitor), linoleic acid (LA) and eicosapentaenoic acid (EPA) (fatty acids associated with indolent PCa), which were able to completely abrogate the hypoxia-induced changes in Zeb1 expression. "

Related Drugs and Biologics

1.	Lipids
2.	Ether (Diethyl Ether)
3.	Linoleic Acid (Linoleate)
4.	Eicosapentaenoic Acid
5.	Membrane Lipids
6.	Ion Channels (Ion Channel)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Antineoplastic Agents (Antineoplastics)
9.	pyrene
10.	edelfosine