monomethoxy (polyethylene glycol)- poly(lactide- co- glycolide)- poly(lysine)

structure in first source

Also Known As:

mPEG-PLGA-b-PLL; monomethoxy (polyethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine)

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
  - Polyesters: 921
    - monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
  - Polyesters: 921
    - monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
      - Polyesters: 921
        monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - Polyethylene Glycols: 3865
        monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Polylysine: 237
    - monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
- Amino Acids: 30675
  - Basic Amino Acids: 178
    - Lysine: 6737
      - Polylysine: 237
        monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4
  - Diamino Amino Acids: 101
    - Lysine: 6737
      - Polylysine: 237
        monomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine): 4

Experts

1.	Duan, Yourong: 4 articles (10/2016 - 06/2012)
2.	Wang, Qi: 3 articles (10/2016 - 06/2012)
3.	Liu, Peifeng: 3 articles (01/2014 - 06/2012)
4.	Sun, Ying: 3 articles (01/2014 - 06/2012)
5.	Zhu, Mingjie: 2 articles (06/2012 - 06/2012)
6.	Fang, Yiwei: 1 article (10/2016)
7.	Fu, Hao: 1 article (10/2016)
8.	Han, Baoshan: 1 article (10/2016)
9.	Qin, Liubing: 1 article (10/2016)
10.	Zhang, Xiangyu: 1 article (10/2016)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 06/01/2012 - "The main purpose of this study was to evaluate the targeting effect of cyclic arginine-glycine-aspartic peptide (cRGD)-modified monomethoxy (polyethylene glycol)-poly (D, L-lactide-co-glycolide)-poly (L-lysine) nanoparticles (mPEG-PLGA-PLL-cRGD NPs) for gastric cancer SGC-7901 cells. "
2.	Carcinoma (Carcinomatosis) 06/01/2012 - "MTT assays used to study the in vitro cytotoxicity of mPEG-PLGA-b-PLL NPs showed that these particles were not toxic in huh-7 hepatic carcinoma cells. " 06/01/2012 - "In vivo the targeting delivery of adriamycin or siRNA mediated by mPEG-PLGA-b-PLL NPs in the huh-7 hepatic carcinoma-bearing mice was evaluated using a fluorescence imaging system. "
3.	Neoplasms (Cancer) 06/01/2012 - "The targeting delivery results and froze section analysis confirmed that drug or siRNA is deliver to tumor more efficiently by mPEG-PLGA-b-PLL NPs than free drug or Lipofectamine™2000. "
4.	Lung Neoplasms (Lung Cancer) 10/01/2016 - "To investigate the therapeutic effect on lung cancer of simultaneously delivering Dox and Bcl-2-siRNA using epidermal growth factor (EGF) modified monomethoxy (polyethylene glycol)-poly (D, L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-PLL, PEAL) NPs (EGF-PEAL). "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2014 - "Here, we report the cellular uptake mechanism, lysosomal escape, and organelle morphology effect of monomethoxy (polyethylene glycol)-poly (D,L-lactide-co-glycolide)-poly (L-lysine) (mPEG-PLGA-PLL, PEAL) and 4-O-beta-D-Galactopyranosyl-D-gluconic acid (Gal)-modified PEAL (PEAL-Gal) for intracellular delivery to HepG2, Huh7, and PLC hepatoma cells. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Glycine (Aminoacetic Acid)
3.	Arginine (L-Arginine)
4.	mPEG-PLGA-PLL-cRGD
5.	methoxypolyethyleneglycol- poly(lactic- co- glycolic acid)
6.	Therapeutic Uses
7.	Small Interfering RNA (siRNA)
8.	Epidermal Growth Factor (EGF)
9.	Doxorubicin (Adriamycin)
10.	Acids