2- (1- hydroxy- 4- oxocyclohexa- 2,5- dienyl)pyran- 4- one

12/15/2021 - "Taken together, this study proved that RY10-4 could induce apoptosis of breast cancer cells by elevating [Ca2+]m through MCU. "
12/15/2021 - "In the present study, we confirmed the pro-apoptotic effect of RY10-4 on breast cancer cells. "
11/28/2012 - "The results indicated that RY10-4 suppressed proliferation, arrested cell cycle, induced apoptosis and inhibited invasion in MDA-MB-231, MCF-7 and SKBR3 breast cancer cells. "
12/15/2021 - "Our work contributed previously unknown insights into the mechanisms involving in the clinical efficacy of RY10-4 on breast cancer cells, which also advanced calcium homeostasis as a potential target for chemotherapeutic drugs."
01/26/2016 - "However, breast cancer cell lines overexpressing human epidermal growth factor receptor 2 (HER2), SKBR3 and BT474, showed less sensitivity to RY10-4 when compared to breast cancer cells lines expressing lower levels of HER2, such as MDA-MB-231 and MCF-7 cells. "

12/25/2017 - "However, few studies reported the effect of combined application of RY10-4 and chemotherapeutic drugs against cancer cells with multidrug resistance (MDR). "
10/01/2014 - "Our studies give the theoretical basis for the possible clinical applications of RY10-4 alone or in combination with other chemotherapeutic drugs in the treatment of MDR tumors. "
12/25/2017 - "RY10-4, an anti-tumor agent, exerts cytotoxicity to various human cancer cell lines. "
12/25/2017 - "Anti-tumor compound RY10-4 suppresses multidrug resistance in MCF-7/ADR cells by inhibiting PI3K/Akt/NF-κB signaling."
01/26/2016 - "In addition, we previously found RY10-4 could inhibit tumor growth through the PI3K/AKT pathway. "

01/01/2016 - "A previous screening study showed that RY10-4 possessed anti-proliferative effects against HepG2 human hepatocellular carcinoma cells. "
01/01/2016 - "In addition, RY10-4 inhibited the proliferation of Hep3B and HuH-7 human hepatocellular carcinoma cells in a concentration-dependent manner. "

05/01/2014 - "As the results showed, the MAPK pathway and the spread of β-catenin were affected by RY10-4 to exert the anti-metastasis on MDA-MB-231. "
05/01/2014 - "RY10-4 suppressed metastasis of MDA-MB-231 by stabilizing ECM and E-cadherin."
05/01/2014 - "In the article, we investigated the anti-metastasis mechanism of RY10-4, an anti-tumor compound derived from protoapigenone, in breast tumor cells MB-MDA-231. "

01/01/2016 - "Taken together, our results suggest that RY10-4 has a great potential to develop as chemotherapeutic agent for liver cancer. "
01/01/2016 - "RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis In Vitro and In Vivo."