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2- (2- bromophenyl)- 3- ((4- (1- methylpiperazine)amino)phenyl)acrylonitrile

an inverse agonist of both PPARbeta and PPARdelta; structure in first source

Also Known As:

DG172

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - Acrylonitrile: 231
    - 2-(2-bromophenyl)-3-((4-(1-methylpiperazine)amino)phenyl)acrylonitrile: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 2-(2-bromophenyl)-3-((4-(1-methylpiperazine)amino)phenyl)acrylonitrile: 1

Experts

1.	Adhikary, T: 1 article (10/2013)
2.	Brandt, D T: 1 article (10/2013)
3.	Diederich, W E: 1 article (10/2013)
4.	Finkernagel, F: 1 article (10/2013)
5.	Grosse, R: 1 article (10/2013)
6.	Jarek, M: 1 article (10/2013)
7.	Kaddatz, K: 1 article (10/2013)
8.	Lieber, S: 1 article (10/2013)
9.	Meissner, W: 1 article (10/2013)
10.	Müller, R: 1 article (10/2013)

Related Diseases

1.	Neoplasms (Cancer) 10/31/2013 - "Repression of ANGPTL4 transcription by inverse PPARβ/δ agonists is functionally linked to the inhibition of cancer cell invasion into a three-dimensional matrix, as (i) invasion of MDA-MB-231 cells is critically dependent on ANGPTL4 expression, (ii) recombinant ANGPTL4 stimulates invasion, and (iii) reverses the inhibitory effect of ST247 and DG172. "
2.	Breast Neoplasms (Breast Cancer) 10/31/2013 - "We show that two structurally divergent inhibitory ligands for PPARβ/δ, the inverse agonists ST247 and DG172, strongly inhibit the serum- and transforming growth factor β (TGFβ)-induced invasion of MDA-MB-231 human breast cancer cells into a three-dimensional matrigel matrix. "

Related Drugs and Biologics

1.	Transforming Growth Factors (Transforming Growth Factor)
2.	Ligands
3.	methyl 3- (N- (4- (hexylamino)- 2- methoxyphenyl)sulfamoyl)thiophene- 2- carboxylate
4.	matrigel