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GPU-167

fluorescent probe for imaging tumor hypoxia; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkynes: 217
      - Carbocyanines: 74
        GPU-167: 1
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - GPU-167: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        GPU-167: 1

Experts

1.	Kadonosono, Tetsuya: 1 article (03/2012)
2.	Kizaka-Kondoh, Shinae: 1 article (03/2012)
3.	Nagasawa, Hideko: 1 article (03/2012)
4.	Okabe, Yasuyuki: 1 article (03/2012)
5.	Okuda, Kensuke: 1 article (03/2012)
6.	Ueno, Takahiro: 1 article (03/2012)
7.	Youssif, Bahaa G M: 1 article (03/2012)

Related Diseases

1.	Neoplasms (Cancer) 03/21/2012 - "In vivo fluorescence imaging specifically detected GPU-167 in tumors 24 h after administration. " 03/21/2012 - "After treatment with GPU-167, tumor cells contained significantly higher levels of fluorescence in hypoxia than in normoxia. "
2.	Hypoxia (Hypoxemia) 03/21/2012 - "After treatment with GPU-167, tumor cells contained significantly higher levels of fluorescence in hypoxia than in normoxia. " 03/21/2012 - "GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two 2-nitroimidazole moieties as exogenous hypoxia markers that undergo bioreductive activation and then selective entrapment in hypoxic cells. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	azomycin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)