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PF-543

Sphingosine Kinase 1 Selective Inhibitor; structure in first source

Also Known As:

1-((4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)phenyl)methyl)-2R-pyrrolidinemethanol; PF543

Networked: 26 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Methanol: 3769
    - PF-543: 26
- Sulfur Compounds: 278
  - Sulfones: 534
    - PF-543: 26
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - PF-543: 26

Experts

1.	Baek, Dong Jae: 4 articles (05/2022 - 01/2018)
2.	Oh, Yoon Sin: 4 articles (05/2022 - 01/2018)
3.	Park, Eun-Young: 4 articles (05/2022 - 01/2018)
4.	Harijith, Anantha: 3 articles (01/2022 - 01/2020)
5.	Natarajan, Viswanathan: 3 articles (01/2022 - 01/2020)
6.	Kim, Sanghee: 3 articles (05/2020 - 01/2018)
7.	Lee, Joo-Youn: 3 articles (05/2020 - 01/2018)
8.	Lee, Taeho: 3 articles (05/2020 - 01/2018)
9.	Kim, Su Bin: 2 articles (05/2022 - 05/2020)
10.	Ha, Alison W: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Airway Remodeling 01/23/2022 - "Treatment of neonatal pups with a sphingosine kinase1 specific inhibitor, PF543, resulted in protection against BPD as neonates, accompanied by improved lung function and reduced airway remodeling as adults. " 01/01/2020 - "Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia."
2.	Fibrosis (Cirrhosis) 01/01/2017 - "However, aggravation of renal fibrosis was detected when SK1 inhibitor PF-543 was applied to suppress SK1 enzymatic activity in UUO mice. " 01/01/2022 - "After treatment of MI rats with PF543, the structure of rat myocardial tissue was significantly improved and the degree of fibrosis was reduced. " 01/01/2022 - "PF543 improved the myocardial structure and function of MI rats and reduced the level of fibrosis and inflammation in MI rats." 08/05/2020 - "We determined whether PF543, a specific SPHK1 inhibitor post bleomycin or asbestos challenge mitigates lung fibrosis by reducing mitochondrial (mt) DNA damage and pro-fibrotic monocyte recruitment-both are implicated in the pathobiology of pulmonary fibrosis. "
3.	Hyperoxia 01/01/2020 - "Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia."
4.	Inflammation (Inflammations) 01/01/2022 - "PF543 improved the myocardial structure and function of MI rats and reduced the level of fibrosis and inflammation in MI rats."
5.	Bronchopulmonary Dysplasia 01/01/2020 - "Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia."

Related Drugs and Biologics

1.	sphingosine kinase
2.	Sphingosine
3.	Triazoles
4.	p38 Mitogen-Activated Protein Kinases
5.	Therapeutic Uses
6.	Phosphates (Orthophosphate)
7.	Epidermal Growth Factor (EGF)
8.	Mitochondrial DNA (mtDNA)
9.	Dextrans (Dextran)
10.	Ceramides

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)