HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (4- (5'- chloro- 3,5- dimethyl- 2,4'- bipyridin- 2'- yl)piperazin- 1- yl)- 3- (methylsulfonyl)propan- 1- one

a potent and selective Smoothened antagonist that penetrates the blood-brain barrier; structure in first source

Also Known As:

PF-5274857

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2,2'-Dipyridyl: 132
      - 1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one: 2
  - Piperazines: 26
    - 1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one: 2

Experts

1.	Chen, Jiao: 1 article (07/2016)
2.	Fan, Ya-Ping: 1 article (07/2016)
3.	Feng, Yun: 1 article (07/2016)
4.	Fu, Jian: 1 article (07/2016)
5.	Li, Qian: 1 article (07/2016)
6.	Zhang, Ping: 1 article (07/2016)
7.	Zhou, Wen-Jie: 1 article (07/2016)
8.	Bartkowski, Darian: 1 article (01/2012)
9.	Lam, Justine L: 1 article (01/2012)
10.	Li, Qing John: 1 article (01/2012)

Related Diseases

1.	Medulloblastoma 01/01/2012 - "In addition, PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. " 01/01/2012 - "Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier."
2.	Neoplasms (Cancer) 01/01/2012 - "These findings suggest that PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway."
3.	Neoplasm Metastasis (Metastasis) 01/01/2012 - "These findings suggest that PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway."
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/01/2016 - "To explore the effects of the Smoothened (Smo) inhibitor PF-5274857 on cigarette smoke (CS)-induced epithelial-mesenchymal transition (EMT) and apply a new idea fororal squamous cell carcinoma (OSCC) treatment. "
5.	Brain Neoplasms (Brain Tumor) 01/01/2012 - "These findings suggest that PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway."

Related Drugs and Biologics

1.	Smoke