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skepinone-L

a dibenzosuberone-type p38 MAPK inhibitor; structure in first source

Also Known As:

CBS3830

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Benzocycloheptenes
        Dibenzocycloheptenes
        skepinone-L: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Benzocycloheptenes
    - Dibenzocycloheptenes
      - skepinone-L: 5

Experts

1.	Laufer, Stefan: 3 articles (12/2019 - 01/2013)
2.	Abendroth, Dietmar-Karl: 2 articles (12/2014 - 09/2013)
3.	Ge, Jian-Jun: 2 articles (12/2014 - 09/2013)
4.	Zhao, Zhi-Wei: 2 articles (12/2014 - 09/2013)
5.	Zhou, Zheng-Chun: 2 articles (12/2014 - 09/2013)
6.	Fuchs, Kerstin: 1 article (12/2019)
7.	Gonzalez-Menendez, Irene: 1 article (12/2019)
8.	Guenthoer, Philipp: 1 article (12/2019)
9.	Kneilling, Manfred: 1 article (12/2019)
10.	Pichler, Bernd J: 1 article (12/2019)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/2013 - "Skepinone-L further markedly blunted thrombus formation under low (500-s) and high (1700-s) arterial shear rates. " 01/01/2013 - "The present study discloses a powerful inhibiting effect of p38 MAPK-blocker Skepinone-L on platelet activation and thrombus formation." 01/01/2013 - "The present study examined the impact of Skepinone-L, a novel and highly selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), on platelet activation and thrombus formation. " 01/01/2013 - "Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation."
2.	Rheumatoid Arthritis 12/01/2019 - "Mitogen-activated protein kinase (MAPK) signaling plays an important role in inflammatory diseases such as rheumatoid arthritis (RA).The aim of our study was to elucidate the therapeutic potential of the highly selective p38 MAPK inhibitor Skepinone-L and the dual inhibitor LN 950 (p38 MAPK and JNK 3) in the K/BxN serum transfer model of RA. "
3.	Hyperplasia 12/01/2014 - "CBS3830 significantly decreases inflammation and intimal hyperplasia in AVGs." 12/01/2014 - "To investigated whether CBS3830, a highly selectively inhibitor of p38MAPK, could ameliorate inflammation and intimal hyperplasia in arterialized vein grafts (AVGs). " 09/01/2013 - "Here, we investigated whether CBS3830 (c-a-i-r biosciences GmbH, Tübingen, Germany), a new highly selectively inhibitor of p38 MAPK, has a significant effect on inhibiting intimal, medial and adventitial hyperplasia. "
4.	Atherosclerosis 01/01/2017 - "Inhibition of a key signaling molecule of the p38 MAPK pathway, p38α MAPK/MAPK14, by selective inhibitors like skepinone-L, conclusively facilitates elucidation of the impact of the complex network of p38 MAPK signaling on atherogenesis and might provide a promising therapeutic tool to prevent inflammatory cascades in atherosclerosis.-Cheng, F., Twardowski, L., Fehr, S., Aner, C., Schaeffeler, E., Joos, T., Knorpp, T., Dorweiler, B., Laufer, S., Schwab, M., Torzewski, M. "
5.	Leukemia 01/01/2017 - "Using the human leukemia cell line THP-1 and/or primary monocyte-derived macrophages, skepinone-L inhibited eLDL-induced activation of the p38 MAPK pathway, inhibited eLDL induced expression of both cluster of differentiation 36 (CD36) and ATP-binding cassette, subfamily A, member 1 (ABCA1), without a net effect on foam cell formation, had a cell- and time-dependent effect on eLDL-triggered apoptosis, and inhibited eLDL-stimulated secretion of IL-8 and MIP-1β/CCL4 (macrophage inflammatory protein-1β/chemokine, CC motif, ligand 4). "

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases
2.	Mitogen-Activated Protein Kinases
3.	LN950
4.	Mitogen-Activated Protein Kinase 14
5.	Therapeutic Uses
6.	CC Chemokines
7.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
8.	Interleukin-8 (Interleukin 8)
9.	Ligands
10.	Autoantibodies