CPSI-121

01/01/2015 - "We have previously shown that treatment with CPSI-121, a guanylhydrazone-derived compound, prevents gut barrier failure after burn injury. "
02/01/2012 - "Similar to direct electrical VNS, CPSI-121 effectively protects the intestinal mucosal barrier from breakdown after severe burn. "
02/01/2012 - "CPSI-121 pharmacologically prevents intestinal barrier dysfunction after cutaneous burn through a vagus nerve-dependent mechanism."
02/01/2012 - "VNS and CPSI-121 administration significantly reduced the permeability to 4-kDa fluorescein isothiocyanate-dextran and maintained normal histology compared with burn. "
02/01/2012 - "Male balb/c mice were subjected to a full-thickness, 30% total body surface area steam burn, and the efficacy of CPSI-121 was tested against vagus nerve stimulation (VNS) postburn at 4 hours. "

01/01/2015 - "CPSI-121 causes efferent VN output and limits shock-induced gut and lung injury as well as ML toxicity. "
01/01/2016 - "ML was collected from male Sprague-Dawley rats after T/HS, trauma-sham shock (T/SS) or T/HS with administration of the pharmacologic vagal agonist CPSI-121. "

01/01/2015 - "T/HS caused gut and lung injury, which were prevented in animals treated with CPSI-121 (p < 0.05). "
01/01/2015 - "CPSI-121 causes efferent VN output and limits shock-induced gut and lung injury as well as ML toxicity. "

01/01/2016 - "ML was collected from male Sprague-Dawley rats after T/HS, trauma-sham shock (T/SS) or T/HS with administration of the pharmacologic vagal agonist CPSI-121. "