HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (7- (2- amino- 6- (4- methylpiperazin- 1- yl)pyrimidin- 4- yl)- 3,4- dihydroisoquinolin- 2(1H)- yl)- 2- cyclopentylethanone

a histamine H4 receptor antagonist with antipruritic and anti-inflammatory activities; structure in first source

Also Known As:

INCB38579

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-cyclopentylethanone: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-cyclopentylethanone: 1

Experts

1.	Bell, Dan: 1 article (01/2012)
2.	Bian, Di: 1 article (01/2012)
3.	Bowman, Kevin: 1 article (01/2012)
4.	Covington, Maryanne: 1 article (01/2012)
5.	Czerniak, Philip: 1 article (01/2012)
6.	Feldman, Patricia: 1 article (01/2012)
7.	He Wang, Kathy: 1 article (01/2012)
8.	He, Xin: 1 article (01/2012)
9.	Hu, Zhijing: 1 article (01/2012)
10.	Krug, Kristin: 1 article (01/2012)

Related Diseases

1.

01/30/2012 - "These results suggest that INCB38579 can serve as a useful tool for pharmacologic characterization of the histamine H₄ receptor and further support the hypothesis that targeting the histamine H₄ receptor may provide new therapeutic agents for various chronic inflammatory diseases, including inflammatory pain."
01/30/2012 - "When examined in formalin-induced pain models, INCB38579 significantly reduces the sustained inflammatory pain experienced by rats and mice. "
01/30/2012 - "INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions."

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Formaldehyde (Formol)