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PF-5212372

inhibits phospholipase A2alpha; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Abraham, William M: 1 article (03/2012)
2.	Calzetta, Luigino: 1 article (03/2012)
3.	Campwala, Hinnah: 1 article (03/2012)
4.	Cazzola, Mario: 1 article (03/2012)
5.	Clark, James D: 1 article (03/2012)
6.	Clarke, Nicholas P: 1 article (03/2012)
7.	Clarke, Philip A: 1 article (03/2012)
8.	Havard, Suzanne: 1 article (03/2012)
9.	Hewson, Christopher A: 1 article (03/2012)
10.	Liu, Wai L: 1 article (03/2012)

Related Diseases

1.	Asthma (Bronchial Asthma) 03/01/2012 - "We investigated a novel cPLA(2)α inhibitor, PF-5212372, to establish the potential of this drug as a treatment for asthma. " 03/01/2012 - "PF5212372 significantly inhibited AMP-induced contraction of human bronchi (81% inhibition; p < 0.001); this finding, together with the ability of this drug to be effective in a wide range of preclinical asthma models, suggests that inhibition of cPLA(2)α with PF-5212372 may represent a new therapeutic option for the treatment of asthma."
2.	Respiratory Hypersensitivity 03/01/2012 - "In a sheep model of allergic inflammation, inhalation of PF-5212372 significantly inhibited late-phase bronchoconstriction (78% inhibition; p < 0.001) and airway hyper-responsiveness (94% inhibition; p < 0.001), and isolated sheep lung mast cell assays confirmed species translation via effective inhibition of PGD(2) release (0.78 nM). "
3.	Inflammation (Inflammations) 03/01/2012 - "In a sheep model of allergic inflammation, inhalation of PF-5212372 significantly inhibited late-phase bronchoconstriction (78% inhibition; p < 0.001) and airway hyper-responsiveness (94% inhibition; p < 0.001), and isolated sheep lung mast cell assays confirmed species translation via effective inhibition of PGD(2) release (0.78 nM). "

Related Drugs and Biologics

1.	Adenosine Monophosphate (AMP)
2.	Prostaglandins D