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N-(3-chlorophenyl)picolinamide

a metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulator; structure in first source

Also Known As:

VU0364770

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolinic Acids: 1
      - N-(3-chlorophenyl)picolinamide: 2
- Heterocyclic Acids
  - Picolinic Acids: 1
    - N-(3-chlorophenyl)picolinamide: 2

Experts

1.	Bubser, Michael: 2 articles (08/2015 - 02/2012)
2.	Conn, P Jeffrey: 2 articles (08/2015 - 02/2012)
3.	Hopkins, Corey R: 2 articles (08/2015 - 02/2012)
4.	Jones, Carrie K: 2 articles (08/2015 - 02/2012)
5.	Lindsley, Craig W: 2 articles (08/2015 - 02/2012)
6.	Niswender, Colleen M: 2 articles (08/2015 - 02/2012)
7.	Thompson, Analisa D: 2 articles (08/2015 - 02/2012)
8.	Cenci, M Angela: 1 article (08/2015)
9.	Iderberg, Hanna: 1 article (08/2015)
10.	Maslava, Natallia: 1 article (08/2015)

Related Diseases

1.	Catalepsy 02/01/2012 - "In addition, VU0364770 enhanced the efficacy of preladenant to reverse haloperidol-induced catalepsy when given in combination. " 02/01/2012 - "When administered alone, VU0364770 exhibited efficacy in reversing haloperidol-induced catalepsy, forelimb asymmetry-induced by unilateral 6-hydroxydopamine (6-OHDA) lesions of the median forebrain bundle, and attentional deficits induced by bilateral 6-OHDA nigrostriatal lesions in rats. "
2.	Dyskinesias (Dyskinesia) 08/01/2015 - "When given together with l-DOPA to rats with already established dyskinesias, neither VU0364770 nor LSP1-2111 modified the abnormal involuntary movement scores. "
3.	Parkinson Disease (Parkinson's Disease) 02/01/2012 - "The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease."

Related Drugs and Biologics

1.	Haloperidol (Haldol)
2.	2- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amine
3.	Levodopa (L Dopa)
4.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
5.	Oxidopamine (6 Hydroxydopamine)
6.	Adenosine (Adenocard)
7.	LSP1 2111