1- (2'- deoxy- 2'- fluoro- arabinofuranosyl)cytosine

a PET tracer

Also Known As:

1-(2'-deoxy-2'-18F-fluoro-arabinofuranosyl)cytosine; 18F-FAC

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Cytarabine: 6662
        1-(2'-deoxy-2'-fluoro-arabinofuranosyl)cytosine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Cytarabine: 6662
        1-(2'-deoxy-2'-fluoro-arabinofuranosyl)cytosine: 3
  - Arabinonucleosides: 1
    - Cytarabine: 6662
      - 1-(2'-deoxy-2'-fluoro-arabinofuranosyl)cytosine: 3

Experts

1.	Chen, Bao Ying: 2 articles (01/2020 - 10/2018)
2.	Clark, Peter M: 2 articles (01/2020 - 10/2018)
3.	Witte, Owen N: 2 articles (01/2020 - 10/2018)
4.	Bahr, Amber: 1 article (01/2021)
5.	Burnazi, Eva M: 1 article (01/2021)
6.	Chang, Qing: 1 article (01/2021)
7.	Grkovski, Milan: 1 article (01/2021)
8.	Humm, John L: 1 article (01/2021)
9.	Kalidindi, Teja M: 1 article (01/2021)
10.	Kulick, Amanda: 1 article (01/2021)

Related Diseases

1.	Autoimmune Hepatitis 10/01/2018 - "18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis." 10/01/2018 - "Results: Hepatic accumulation of 18F-FDG and 18F-FAC was 173% and 61% higher, respectively, and hepatic accumulation of 18F-DFA was 41% lower, in a mouse model of autoimmune hepatitis than in control mice. " 10/01/2018 - "18F-FAC PET provided a noninvasive biomarker of the efficacy of dexamethasone for treating the autoimmune hepatitis model. " 10/01/2018 - "Infiltrating leukocytes in liver biopsy samples from patients with autoimmune hepatitis express high levels of deoxycytidine kinase, a rate-limiting enzyme in the accumulation of 18F-FAC. " 10/01/2018 - "Methods: Mice treated with concanavalin A (ConA) to induce a model of autoimmune hepatitis or vehicle were imaged with 18F-FDG, 18F-FAC, and 18F-DFA PET. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2021 - "We compared tumor 18F-FAC PET images with 14C-gemcitabine levels, established ex vivo, in 3 mouse models of pancreatic cancer. " 01/01/2021 - "Predicting Gemcitabine Delivery by 18F-FAC PET in Murine Models of Pancreatic Cancer."
3.	Neoplasms (Cancer) 01/01/2021 - "Results: Tumor-to-muscle ratios of 14C-gemcitabine and 18F-FAC correlated well across all PDX models and treatments (R2 = 0.78). " 01/01/2021 - "Tumor and muscle uptake of both 18F-FAC and 14C-gemcitabine was obtained ex vivo. " 01/01/2021 - "We compared tumor 18F-FAC PET images with 14C-gemcitabine levels, established ex vivo, in 3 mouse models of pancreatic cancer. " 01/01/2021 - "PET/MR 18F-FAC images showed a 12% increase in tumor 18F-FAC uptake after PEGPH20 treatment (P = 0.023). " 01/01/2021 - "18F-FAC (2'-deoxy-2'-18F-fluoro-β-d-arabinofuranosylcytosine) has close structural similarity to gemcitabine and thus offers the potential to image drug delivery to tumors. "
4.	Multiple Sclerosis 01/01/2020 - "18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis."
5.	Hepatitis 10/01/2018 - "In contrast, viral hepatitis increased hepatic 18F-FDG accumulation by 109% and decreased hepatic 18F-DFA accumulation by 20% but had no effect on hepatic 18F-FAC accumulation (nonsignificant 2% decrease). " 10/01/2018 - "For comparison, mice treated with an adenovirus to induce a viral hepatitis were imaged with 18F-FDG, 18F-FAC, and 18F-DFA PET. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Dexamethasone (Maxidex)
3.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
4.	Hyaluronoglucosaminidase (Hyaluronidase)
5.	Enzymes
6.	Deoxycytidine Kinase
7.	Concanavalin A
8.	Gemcitabine
9.	PEGPH20

Related Therapies and Procedures

1.	Injections