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KRP-109

structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - KRP-109: 2
  - Oxazines: 9
    - Benzoxazines: 58
      - KRP-109: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazines: 58
      - KRP-109: 2

Experts

1.	Chillappagari, Shashi: 1 article (01/2016)
2.	Guenther, Andreas: 1 article (01/2016)
3.	Henke, Markus O: 1 article (01/2016)
4.	Mahavadi, Poornima: 1 article (01/2016)
5.	Müller, Christian: 1 article (01/2016)
6.	Nährlich, Lutz: 1 article (01/2016)
7.	Rosenblum, Jonathan: 1 article (01/2016)
8.	Rubin, Bruce K: 1 article (01/2016)
9.	Araki, Nobuko: 1 article (12/2011)
10.	Harada, Yosuke: 1 article (12/2011)

Related Diseases

1.	Pneumonia (Pneumonitis) 12/01/2011 - "The present results indicate that KRP-109 reduces lung inflammation in a murine model, and that KRP-109 may be useful for the treatment of patients with severe pneumonia." 12/01/2011 - "In this study, the efficacy of KRP-109 was examined using a murine model of severe pneumonia induced by Streptococcus pneumoniae (S. pneumoniae). "
2.	Pneumococcal Pneumonia 12/01/2011 - "In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia."
3.	Inflammation (Inflammations) 12/01/2011 - "The lung tissues of the KRP-109 mice had few neutrophils in the alveolar walls and less inflammation. "
4.	Cystic Fibrosis (Mucoviscidosis) 01/01/2016 - "A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation."

Related Drugs and Biologics

1.	Pancreatic Elastase (Elastase)
2.	Secretory Proteinase Inhibitory Proteins
3.	Mucins