5- (2- (1- (1- (3- hydroxy- 2,3- dimethylbutoxy)ethyl)- 7alpha- methyldihydro- 1H- inden- 4(2H,5H,6H,7H,7alphaH)- ylidene)ethylidene)- 2- methylenecyclohexane- 1,3- diol

a vitamin D receptor modulator and cardioprotective agent; structure in first source

Also Known As:

VS-105

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Secosteroids: 22
      - Vitamin D: 33265
        Cholecalciferol: 4786
        Hydroxycholecalciferols: 25
        Dihydroxycholecalciferols: 2
        Calcitriol: 5322
        5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol: 5
    - Cholestanes
      - Sterols: 2245
        Cholecalciferol: 4786
        Hydroxycholecalciferols: 25
        Dihydroxycholecalciferols: 2
        Calcitriol: 5322
        5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol: 5
      - Cholestenes
        Cholecalciferol: 4786
        Hydroxycholecalciferols: 25
        Dihydroxycholecalciferols: 2
        Calcitriol: 5322
        5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol: 5
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - Cholecalciferol: 4786
      - Hydroxycholecalciferols: 25
        Dihydroxycholecalciferols: 2
        Calcitriol: 5322
        5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol: 5

Experts

1.	Chen, Yung-Wu: 3 articles (12/2020 - 09/2011)
2.	Wu-Wong, J Ruth: 3 articles (12/2020 - 09/2011)
3.	Wessale, Jerry L: 2 articles (12/2020 - 02/2015)
4.	Atsawasuwan, Phimon: 1 article (12/2020)
5.	Chen, Theresa: 1 article (12/2020)
6.	Oubaidin, Maysaa: 1 article (12/2020)
7.	Fujii, Hideki: 1 article (01/2017)
8.	Goto, Shunsuke: 1 article (01/2017)
9.	Kono, Keiji: 1 article (01/2017)
10.	Nakai, Kentaro: 1 article (01/2017)

Related Diseases

1.	Bone Resorption 12/01/2020 - "VS-105 is efficacious in improving BMD in a dose range that does not affect serum Ca in OVX rats; the improvement in BMD by VS-105 is attributable to increased osteoblastic activity and reduced osteoclastic bone resorption."
2.	Chronic Renal Insufficiency 01/01/2017 - "In the present study, we compared the effects of VS-105 and paricalcitol on chronic kidney disease-mineral bone disorder (CKD-MBD) in a CKD rat model. " 01/01/2017 - "Comparison of the effects of novel vitamin D receptor analog VS-105 and paricalcitol on chronic kidney disease-mineral bone disorder in an experimental model of chronic kidney disease."
3.	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 01/01/2017 - "Our data suggest that VS-105 had a lesser effect on CKD-MBD than paricalcitol except in the case of serum PTH levels. " 01/01/2017 - "In the present study, we compared the effects of VS-105 and paricalcitol on chronic kidney disease-mineral bone disorder (CKD-MBD) in a CKD rat model. "
4.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 02/15/2015 - "Enalapril or VS-105 alone significantly reduced left ventricular hypertrophy (LVH); VS-105 plus enalapril did not further reduce LVH. " 09/01/2011 - "Male Sprague-Dawley rats were 5/6 nephrectomized and 6 weeks later, after they had established uraemia, elevated parathyroid hormone levels, endothelial dysfunction and left ventricular hypertrophy, the rats were treated with VS-105, a novel VDRM. "
5.	Postmenopausal Osteoporosis 12/01/2020 - "A Novel Vitamin D Receptor Agonist, VS-105, Improves Bone Mineral Density without Affecting Serum Calcium in a Postmenopausal Osteoporosis Rat Model."

Related Drugs and Biologics

1.	paricalcitol (Zemplar)
2.	Minerals
3.	Calcitriol Receptors (Calcitriol Receptor)
4.	Propylene Glycol (1,2 Propanediol)
5.	Parathyroid Hormone (Parathormone)
6.	Enalapril
7.	Calcium
8.	Calcitriol (Calcijex)