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iodobenzoylnaltrexamide

structure in first source

Also Known As:

IBNtxA

Networked: 5 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Majumdar, Susruta: 5 articles (07/2021 - 09/2014)
2.	Pasternak, Gavril W: 5 articles (07/2021 - 09/2014)
3.	Pan, Ying-Xian: 3 articles (01/2018 - 10/2014)
4.	Grinnell, Steven G: 2 articles (07/2021 - 09/2014)
5.	Lu, Zhigang: 2 articles (01/2018 - 07/2015)
6.	Rossi, Grace C: 2 articles (01/2018 - 07/2015)
7.	Xu, Jin: 2 articles (01/2018 - 07/2015)
8.	Hunkele, Amanda: 1 article (07/2021)
9.	Pan, Ying Xian: 1 article (07/2021)
10.	Subrath, Joan: 1 article (07/2021)

Related Diseases

1.	Pain (Aches) 10/01/2014 - "The current study demonstrates potent and efficacious IBNtxA inhibition of a wide variety of assays, including inflammatory and neuropathic hypersensitivity and spontaneous pain. " 07/01/2021 - "Previously, we have shown that IBNtxA is a potent analgesic effective in a spectrum of pain models but lacks many side-effects associated with traditional opiates. " 10/01/2014 - "A recently synthesized compound, iodobenzoylnaltrexamide (IBNtxA), acting at 6-transmembrane (6-TM) splice variants of the μ-opioid receptor gene, was shown to have potent analgesic actions against acute, thermal pain accompanied by a vastly improved side-effect profile compared to 7-TM-acting drugs such as morphine. "
2.	Hypersensitivity (Allergy) 10/01/2014 - "The current study demonstrates potent and efficacious IBNtxA inhibition of a wide variety of assays, including inflammatory and neuropathic hypersensitivity and spontaneous pain. "
3.	Respiratory Insufficiency (Respiratory Failure) 09/01/2014 - "IBNtxA displays no respiratory depression as measured by blood oxygen saturation. " 09/01/2014 - "Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA." 01/01/2018 - "Three-iodobenzoyl-6β-naltrexamide (IBNtxA) is a novel class of opioid active against thermal, inflammatory, and neuropathic pain, without respiratory depression, physical dependence, and reward behavior. "
4.	Neuralgia (Stump Neuralgia) 01/01/2018 - "Three-iodobenzoyl-6β-naltrexamide (IBNtxA) is a novel class of opioid active against thermal, inflammatory, and neuropathic pain, without respiratory depression, physical dependence, and reward behavior. " 07/01/2015 - "In contrast, 3-iodobenzoyl-6β-naltrexamide (IBNtxA) is a potent analgesic against thermal, inflammatory, and neuropathic pain that acts independently of 7TM μ-opioid receptors but has no activity in mice lacking a set of 6TM truncated μ-opioid receptor splice variants. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	iodobenzoylnaltrexamide
3.	Opioid Receptors (Opioid Receptor)
4.	Opiate Alkaloids
5.	Morphine (MS Contin)
6.	Opioid Analgesics (Opioids)