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N- (4- (N- (3- methoxypyrazin- 2- yl)sulfamoyl)phenyl)- 3- (5- nitrothiophene- 2- yl)acrylamide

prevents the necrosome from interacting with downstream effectors; structure in first source

Also Known As:

necrosulfonamide

Networked: 26 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Lei, Xiaoguang: 2 articles (01/2020 - 01/2012)
2.	Bradley, Jennifer L: 1 article (07/2022)
3.	Ge, Weiwei: 1 article (07/2022)
4.	He, Fenglian: 1 article (07/2022)
5.	Hu, Juntao: 1 article (07/2022)
6.	Ji, Xianfei: 1 article (07/2022)
7.	Ornato, Joseph P: 1 article (07/2022)
8.	Peberdy, Mary Ann: 1 article (07/2022)
9.	Tang, Wanchun: 1 article (07/2022)
10.	Zheng, Guanghui: 1 article (07/2022)

Related Diseases

1.	Inflammation (Inflammations) 12/01/2022 - "Necrosulfonamide ameliorates intestinal inflammation via inhibiting GSDMD-medicated pyroptosis and MLKL-mediated necroptosis." 11/01/2021 - "Moreover, a higher inflammatory response was detected in HK‑2 cells with RIP3 overexpression, and this elevated inflammation could be restored by the necroptosis inhibitor necrosulfonamide. " 01/01/2022 - "Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis."
2.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2019 - "Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity." 06/01/2018 - "Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition."
3.	Mitochondrial Diseases (Mitochondrial Disease) 09/05/2022 - "Importantly, the MLKL inhibitor necrosulfonamide (NSA) dramatically attenuated gESCs necroptosis and powerfully blocked ZEA-induced reactive oxygen species (ROS) generation and mitochondrial dysfunction. " 01/01/2019 - "Mixed-lineage kinase domain-like protein (MLKL) is a critical signal molecule of necroptosis, and mitochondrial dysfunction is regarded as one of the most pivotal events after SCI. Based on the important role of MLKL in cell damage and potential role of mitochondrial dysfunction, our study focuses on the regulation of MLKL by Necrosulfonamide (NSA) in mitochondrial dysfunction of oxygen-glucose deprivation (OGD)-induced cell damage and SCI-mice, which specifically blocks the MLKL. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/17/2017 - "This study aimed to investigate the protective effect of the necroptosis inhibitor necrosulfonamide (NSA) on intestinal epithelial cells using a novel in vitro necroptosis model that mimics inflammatory bowel disease (IBD). "
5.	Heart Arrest (Cardiac Arrest) 07/05/2022 - "This study aimed to explore the effect of necrosulfonamide (NSA) on post-resuscitation myocardial dysfunction in a rat model of cardiac arrest. " 07/05/2022 - "Necrosulfonamide improves post-resuscitation myocardial dysfunction via inhibiting pyroptosis and necroptosis in a rat model of cardiac arrest."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Proteins (Proteins, Gene)
3.	Oxygen (Dioxygen)
4.	Glucose (Dextrose)
5.	Caspases
6.	Neuroprotective Agents
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	ferrostatin-1
9.	Inflammasomes
10.	Endosomal Sorting Complexes Required for Transport

Related Therapies and Procedures

1.	Resuscitation