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SB 747651A

inhibits mitogen- and stress-activated kinase 1; structure in first source

Also Known As:

SB-747651A; SB747651A

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        SB 747651A: 1
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - SB 747651A: 1

Experts

1.	Boldt, Henning Bünsow: 1 article (01/2021)
2.	Jakobsen, Elisabeth Victoria: 1 article (01/2021)
3.	Knudsen, Arnon Møldrup: 1 article (01/2021)
4.	Kristensen, Bjarne Winther: 1 article (01/2021)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 01/01/2021 - "In this study we investigated the anticancer effects of SB747651A, a multi-target small-molecule inhibitor, in three well characterized patient-derived glioblastoma spheroid cultures and a murine orthotopic xenograft model. " 01/01/2021 - "These findings suggest that SB747651A has anticancer effects in glioblastoma. " 01/01/2021 - "The multi-target small-molecule inhibitor SB747651A shows in vitro and in vivo anticancer efficacy in glioblastomas." 01/01/2021 - "Expression levels of cancer stemness marker SOX2 were reduced in treated tumor cells and SB747651A treatment significantly prolonged survival of mice with intracranial glioblastoma xenografts, while no adverse effects were observed in vivo at doses of 25 mg/kg administered 5 days/week for 8 weeks. "
2.	Neoplasms (Cancer) 01/01/2021 - "Expression levels of cancer stemness marker SOX2 were reduced in treated tumor cells and SB747651A treatment significantly prolonged survival of mice with intracranial glioblastoma xenografts, while no adverse effects were observed in vivo at doses of 25 mg/kg administered 5 days/week for 8 weeks. " 01/01/2021 - "The cancer-related pathophysiological mechanisms targeted by SB747651A are shared among many types of cancer; however, an in-depth clarification of the mechanisms of action in cancer cells is important before further potential application of SB747651A as an anticancer agent can be considered."

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)