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TASP0277308

immunomodulator and sphingosine 1-phosphate receptor antagonist; structure in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - TASP0277308: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - TASP0277308: 4

Experts

1.	Salvemini, Daniela: 2 articles (01/2018 - 09/2017)
2.	Fujii, Yasuyuki: 2 articles (03/2012 - 01/2012)
3.	Goitsuka, Ryo: 2 articles (03/2012 - 01/2012)
4.	Igarashi, Yasuyuki: 2 articles (03/2012 - 01/2012)
5.	Nakazawa, Kiyoshi: 2 articles (03/2012 - 01/2012)
6.	Ohtake, Hidenori: 2 articles (03/2012 - 01/2012)
7.	Ono, Naoya: 2 articles (03/2012 - 01/2012)
8.	Takayama, Tetsuo: 2 articles (03/2012 - 01/2012)
9.	Campolo, Michela: 1 article (01/2018)
10.	Cuzzocrea, Salvatore: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2017 - "Intrathecal or systemic administration of the competitive and functional S1PR1 antagonists, TASP0277308 and FTY720/Fingolimod, respectively, attenuated cancer-induced spontaneous flinching and guarding. " 03/23/2012 - "Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo. " 03/23/2012 - "These findings revealed that S1P(1) is a critical component of VEGF-related angiogenic responses and also provide evidence for the efficacy of TASP0277308 for anti-cancer therapies."
2.	Wounds and Injuries (Trauma) 01/01/2018 - "Mice were injected intraperitoneally with siponimod or TASP0277308 (1 mg/kg) at 1 and 4 h post-trauma. "
3.	Lymphopenia (Lymphocytopenia) 01/01/2012 - "Furthermore, differing from previously reported S1P(1) antagonists, TASP0277308 demonstrated in vivo activities to induce lymphopenia, a block in T cell egress from the thymus, displacement of marginal zone B cells, and upregulation of CD69 expression on both T and B cells, all of which recapitulate phenotypes of S1P(1)-deficient lymphocytes. "
4.	Experimental Arthritis 01/01/2012 - "In a mouse collagen-induced arthritis model, TASP0277308 significantly suppressed the development of arthritis, even after the onset of disease. "
5.	Arthritis (Polyarthritis) 01/01/2012 - "In a mouse collagen-induced arthritis model, TASP0277308 significantly suppressed the development of arthritis, even after the onset of disease. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Fingolimod Hydrochloride (FTY720)
3.	siponimod

Related Therapies and Procedures

1.	Therapeutics