TB-403

Phase I double-blind, dose escalation study directed against placental growth factor in healthy male subjects

Also Known As:

RO-5323441; RO5323441; TB-403 monoclonal antibody; TB403; THR 317; THR-317

Networked: 10 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tessier, Jean: 3 articles (01/2017 - 06/2013)
2.	Carmeliet, Peter: 2 articles (01/2022 - 06/2009)
3.	Habben, Kai: 2 articles (01/2017 - 07/2015)
4.	Krieter, Oliver: 2 articles (01/2017 - 07/2015)
5.	Lahr, Angelika: 2 articles (01/2017 - 07/2015)
6.	Wang, Ka: 2 articles (01/2017 - 07/2015)
7.	Bergendahl, Genevieve: 1 article (01/2022)
8.	Bielamowicz, Kevin: 1 article (01/2022)
9.	De Deene, A: 1 article (01/2022)
10.	Duda, Dan G: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2009 - "Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients." 01/01/2015 - "Human ccRCCs were implanted in athymic nude mice to evaluate the efficacy of TB403 and to excise xenograft tumors for molecular experiments. " 01/01/2022 - "We conducted a phase I, open-label, multicenter, dose-escalation study of TB-403 in pediatric subjects with relapsed or refractory cancers. " 01/01/2017 - "A two-compartment linear population PK model was developed from these four studies to characterize the PK of RO5323441 in patients with cancer. " 06/01/2013 - "We therefore aimed to radiolabel RO5323441 and preclinically validate this tracer to study drug tumor uptake and organ distribution by PET imaging. "
2.	Alveolar Rhabdomyosarcoma 01/01/2022 - "A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma."
3.	Ewing Sarcoma (Sarcoma, Ewing) 01/01/2022 - "A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma."
4.	Neuroblastoma 01/01/2022 - "A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma."
5.	Medulloblastoma 01/01/2022 - "TB-403 is a blocking monoclonal antibody against PlGF that inhibits tumor growth and increases survival in orthotopic medulloblastoma models. " 01/01/2022 - "A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma."

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Bevacizumab (Avastin)
4.	Dystroglycans (Dystroglycan)
5.	Laminin (Merosin)
6.	Sunitinib (Sutent)
7.	pyrimidine