Trichophyton infection

Infection by fungi of the genus TRICHOPHYTON, especially Trichophyton rubrum, which is the leading cause of tinea.

Also Known As:

Deep dermatophytosis; Granuloma trichophyticum; Majocchi's granuloma; Trichophyton infections; Trichophyton rubrum infection; Trichophyton rubrum infections; deep seated dermatophytosis; trichophytic granuloma

Networked: 97 relevant articles (8 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tinea Capitis
2.	Infections
3.	Diabetes Mellitus
4.	Tinea (Ringworm)
5.	Onychomycosis (Tinea Unguium)

Experts

1.	Lanternier, Fanny: 3 articles (07/2015 - 12/2013)
2.	Puel, Anne: 3 articles (07/2015 - 12/2013)
3.	Gupta, A K: 2 articles (12/2018 - 11/2000)
4.	Bennett, Cathy: 2 articles (02/2017 - 05/2016)
5.	Chen, Xiaomei: 2 articles (02/2017 - 05/2016)
6.	González, Urbà: 2 articles (02/2017 - 05/2016)
7.	Hua, Xia: 2 articles (02/2017 - 05/2016)
8.	Jiang, Xia: 2 articles (02/2017 - 05/2016)
9.	Lin, Xiufang: 2 articles (02/2017 - 05/2016)
10.	Xue, Siliang: 2 articles (02/2017 - 05/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Trichophyton infection:

1.	Terbinafine (Lamisil)FDA LinkGeneric 06/01/2017 - "After confirmed as Majocchi's granuloma, the patient was cured after 11-month treatment with terbinafine." 01/01/2022 - "Paradoxical inflammatory reaction to terbinafine in the setting of Majocchi's granuloma due to Trichophyton interdigitale." 01/01/2022 - "Majocchi's granuloma on the scalp of a 55-year-old female successfully treated with terbinafine." 03/01/2021 - "Terbinafine is a first-line agent against Trichophyton-infections. " 01/01/2019 - "Deep Dermatophytosis Caused by Trichophyton verrucosum in an Immunosuppressed Patient: Successful Outcome with Terbinafine."
2.	Griseofulvin (Grifulvin V)FDA LinkGeneric 07/01/1965 - "THE TREATMENT OF TRICHOPHYTON RUBRUM INFECTIONS OF THE TOENAILS AND FEET WITH A NEW ULTRAFINE FORM OF GRISEOFULVIN." 04/01/1964 - "TRICHOPHYTON RUBRUM INFECTION RESISTANT TO GRISEOFULVIN." 02/01/1962 - "Lupus erythematosus in two patients after griseofulvin treatment of Trichophyton rubrum infection." 11/01/1961 - "Trichophyton rubrum Infection with Griseofulvin Intolerance." 06/01/1960 - "Recurrence of Trichophyton rubrum infection during treatment with griseofulvin. "
3.	Itraconazole (Sporanox)FDA LinkGeneric 08/01/2017 - "Deep Dermatophytosis Caused by Zoophilic Strain of Trichophyton interdigitale with Successful Treatment of Itraconazole." 09/28/2012 - "In patients with Trichophyton rubrum infections, refractory to itraconazole treatment, altered drug absorption or drug interactions has to be considered. " 05/01/1998 - "Two pulses of oral itraconazole therapy thus appear to be effective in the treatment of Majocchi's granuloma, and it is possible that one pulse may be sufficient in some patients. " 08/01/2017 - "We report a 66-year-old female patient with deep dermatophytosis caused by zoophilic strain of Trichophyton interdigitale, a rare granulomatous presentation of Trichophyton species infection in patients with underlying systemic diseases, and she was successfully cured by itraconazole. " 10/01/2012 - "To the authors' knowledge, this is the first report of Trichophyton infection in a fennec fox and, although a postmortem examination was not performed, this is possibly the first report of fatal acute liver failure associated with itraconazole in a canid."
4.	AlloxanIBA 01/01/2017 - "In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). "
5.	Clotrimazole (Lotrimin)FDA LinkGeneric 01/01/2023 - "After fungal culture and identification, the patient was diagnosed with Trichophyton rubrum infection, and was cured after 3 weeks of topical use of clotrimazole cream." 10/30/1992 - "In vitro and in vivo topical antifungal activity against both dermatophytes and Candida species varied widely, but 13c proved to be significantly superior to both 1 and clotrimazole against a vaginal Candida infection in hamsters, while 13b was significantly more active than 1 against a a topical Trichophyton infection in guinea pigs. "
6.	Ketoconazole (Nizoral)FDA LinkGeneric 03/01/1984 - "Successful use of ketoconazole for invasive cutaneous Trichophyton rubrum infection." 09/01/1990 - "An overview of current practice in the use of topical and oral agents, especially ketoconazole, are given in the following specific mycoses: tinea capitis, pityriasis versicolor, seborrheic dermatitis, Trichophyton rubrum infections, vaginal candidiasis, and moist intertriginous tineas. " 03/01/1981 - "This study demonstrates the efficacy and safety of ketoconazole, a broad-spectrum oral antifungal agent administered to 20 patients with severe, extensive, and recalcitrant Trichophyton rubrum infection. "
7.	Antifungal AgentsIBA 03/01/1981 - "This study demonstrates the efficacy and safety of ketoconazole, a broad-spectrum oral antifungal agent administered to 20 patients with severe, extensive, and recalcitrant Trichophyton rubrum infection. " 01/01/2016 - " information, including time span, clinical features, histological findings, and improvement following withdrawal of adalimumab and treatment with an oral antifungal agent, indicates that Majocchi's granuloma was adalimumab-related. " 06/01/2019 - "To evaluate itch caused by Trichophyton infection and the effect of antifungal agents on the infection, by measuring scratch behaviour and profiles of inflammatory cytokines and chemokines. "
8.	Glucose (Dextrose)FDA LinkGeneric 07/01/1969 - "Oral glucose tolerance studies in recurrent Trichophyton rubrum infections."
9.	AgarIBA 08/01/1985 - "Studies on the parasitic forms of Trichophyton rubrum isolated from patients with granuloma trichophyticum using the "agar-implantation method"."
10.	Proteins (Proteins, Gene)FDA Link 07/01/2015 - "Recently, CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in individuals with deep dermatophytosis previously classified as "immunocompetent". " 02/01/2015 - "Autosomal recessive deficiency of the CARD9 (caspase recruitment domain 9) protein has been described in 17 patients with deep dermatophytosis from Algeria, Tunisia, and Morocco. " 10/07/2023 - "However, a caspase recruitment domain-containing protein 9 (CARD9) deficiency has recently been reported to cause deep dermatophytosis. " 01/01/2022 - "Deep dermatophytosis is often associated with Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in patients. " 12/01/2013 - "Inborn errors of interleukin-17 immunity have recently been shown to underlie chronic mucocutaneous candidiasis (CMC), while inborn errors of caspase recruitment domain-containing protein 9 (CARD9) immunity underlie deep dermatophytosis and invasive candidiasis. "

Therapies and Procedures

1.	Therapeutics 05/01/1988 - "Five patients with recurrent Trichophyton rubrum infections had become unresponsive to topical and oral antifungal therapy. " 11/01/2005 - "Majocchi's granuloma is a rare complication with immunosuppression, but is significant to consider when a fungal infection is suspected because it may require more aggressive therapy." 05/01/1998 - "Two pulses of oral itraconazole therapy thus appear to be effective in the treatment of Majocchi's granuloma, and it is possible that one pulse may be sufficient in some patients. " 01/01/2014 - "Majocchi's Granuloma after Topical Corticosteroids Therapy." 07/01/1986 - "Majocchi's granuloma (due to therapy with steroid and occlusion)."
2.	Liver Transplantation 01/01/2022 - "Invasive Trichophyton infection in a liver transplant recipient." 05/01/2009 - "Majocchi's granuloma in a liver transplant recipient caused by a Trichophyton spp., phenotypically consistent with Trichophyton rubrum var. raubitschekii." 05/01/2009 - "The authors report a case of Majocchi's granuloma and onychomycosis in a liver transplant recipient caused by a Trichophyton spp., phenotypically consistent with Trichophyton rubrum var. raubitschekii. " 04/01/2010 - "Majocchi's granuloma after antithymocyte globulin therapy in a liver transplant patient."
3.	Hematopoietic Stem Cell Transplantation 01/01/2022 - "Majocchi's granuloma in a patient with GATA2 haploinsufficiency undergoing hematopoietic stem cell transplantation."
4.	Cryotherapy (Therapy, Cold) 10/08/2012 - "Trichophyton mentagrophytes-associated Majocchi's granuloma treated with cryotherapy."
5.	Kidney Transplantation 12/01/2006 - "Majocchi's granuloma after kidney transplantation."