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3- ((5- ((1,2,4)triazolo(1,5- a)pyridin- 6- yl)- 4- (6- methylpyridin- 2- yl)thiazol- 2- ylamino)methyl)benzonitrile

inhibits ALK5 protein

Also Known As:

EW 7203; EW-7203; EW7203

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 3-((5-((1,2,4)triazolo(1,5-a)pyridin-6-yl)-4-(6-methylpyridin-2-yl)thiazol-2-ylamino)methyl)benzonitrile: 1
  - Pyridines: 88
    - 3-((5-((1,2,4)triazolo(1,5-a)pyridin-6-yl)-4-(6-methylpyridin-2-yl)thiazol-2-ylamino)methyl)benzonitrile: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 3-((5-((1,2,4)triazolo(1,5-a)pyridin-6-yl)-4-(6-methylpyridin-2-yl)thiazol-2-ylamino)methyl)benzonitrile: 1

Experts

1.	Kim, Dae-Kee: 1 article (10/2011)
2.	Park, Chul-Yong: 1 article (10/2011)
3.	Sheen, Yhun Yhong: 1 article (10/2011)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 10/01/2011 - "The novel ALK5 inhibitor, EW-7203, efficiently inhibited TGF-β1-induced Smad signalling, EMT and breast tumor metastasis to the lung in vivo, demonstrating that EW-7203 has therapeutic potential for breast cancer metastasis to the lung." 10/01/2011 - "Furthermore, in xenografted Balb ⁄ c mice, EW-7203 inhibited metastasis to the lung from breast tumors. " 10/01/2011 - "In addition, the suppressive effects of EW-7203 on mammary cancer metastasis to the lung were examined using a Balb ⁄ c xenograft model system. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2011 - "The novel ALK5 inhibitor, EW-7203, efficiently inhibited TGF-β1-induced Smad signalling, EMT and breast tumor metastasis to the lung in vivo, demonstrating that EW-7203 has therapeutic potential for breast cancer metastasis to the lung." 10/01/2011 - "Furthermore, in xenografted Balb ⁄ c mice, EW-7203 inhibited metastasis to the lung from breast tumors. " 10/01/2011 - "In addition, the suppressive effects of EW-7203 on mammary cancer metastasis to the lung were examined using a Balb ⁄ c xenograft model system. "