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CDX 1307

a fusion protein consisting of a monoclonal antibody against human mannose receptor and hCG-beta antigen

Also Known As:

CDX-1307; CDX1307

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Recombinant Fusion Proteins: 333
      - CDX 1307: 2
Complex Mixtures: 1906
- Biological Products
  - Vaccines: 124365
    - Cancer Vaccines: 4052
      - CDX 1307: 2

Experts

1.	Keler, Tibor: 2 articles (07/2011 - 06/2011)
2.	Morse, Michael A: 2 articles (07/2011 - 06/2011)
3.	Blackwell, Kimberly: 1 article (07/2011)
4.	Butler, Stephen A: 1 article (07/2011)
5.	Chapman, Robert: 1 article (07/2011)
6.	Clay, Timothy: 1 article (07/2011)
7.	Davis, Thomas: 1 article (07/2011)
8.	Green, Jennifer: 1 article (07/2011)
9.	He, Li-Zhen: 1 article (07/2011)
10.	Hobeika, Amy: 1 article (07/2011)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "An ongoing Phase II trial evaluates CDX-1307 in patients with newly diagnosed, resectable, hCG-β-expressing bladder cancer, where low tumor burden and early intervention may provide greater potential for benefit." 07/15/2011 - "Two phase I studies were conducted with CDX-1307, a vaccine composed of human chorionic gonadotropin beta-chain (hCG-β) fused to an MR-specific monoclonal antibody, administered either locally (intradermally) or systemically (intravenously) in patients with advanced epithelial malignancies. " 06/01/2011 - "In Phase I studies of cancer patients, CDX-1307 was well tolerated and induced significant hCG-β-specific cellular and humoral immune responses when co-administered with GM-CSF and the Toll-like receptor agonists resiquimod and poly-ICLC. " 06/01/2011 - "CDX-1307 consists of a human monoclonal antibody targeting the mannose receptor, fused to the human chorionic gonadotropin-β chain (hCG-β), a tumor antigen frequently expressed by epithelial cancers including bladder cancer. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 06/01/2011 - "An ongoing Phase II trial evaluates CDX-1307 in patients with newly diagnosed, resectable, hCG-β-expressing bladder cancer, where low tumor burden and early intervention may provide greater potential for benefit." 06/01/2011 - "CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer." 06/01/2011 - "CDX-1307 consists of a human monoclonal antibody targeting the mannose receptor, fused to the human chorionic gonadotropin-β chain (hCG-β), a tumor antigen frequently expressed by epithelial cancers including bladder cancer. "

Related Drugs and Biologics

1.	Vaccines
2.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
3.	Monoclonal Antibodies
4.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
5.	Toll-Like Receptor Agonists
6.	resiquimod
7.	poly ICLC
8.	Neoplasm Antigens (Tumor Antigens)
9.	Mannose Receptor